Overexpression of Kynurenine 3-Monooxygenase Correlates with Cancer Malignancy and Predicts Poor Prognosis in Canine Mammary Gland Tumors
Joint Authors
Chiu, Yi-Han
Huang, Kuo-Chin
Lin, Chen-Si
Lei, Han-Jung
Chiang, Yi-Lin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tumor biomarkers are developed to indicate tumor status, clinical outcome, or prognosis.
Since currently there are no effective biomarkers for canine mammary tumor (CMT), this study intended to verify whether kynurenine 3-monooxygenase (KMO), one of the key enzymes involved in tryptophan catabolism, is competent for predicting prognosis in patients with CMT.
By investigating a series of 86 CMT clinical cases, we found that both gene and protein expression of KMO discriminated malignant from benign CMTs and was significantly higher in stage IV and V tumors than in lower-stage CMTs.
About 73.7% of malignant CMTs showed strong expression of KMO which correlated with lower overall survival rates in patients.
Further, downregulation of KMO activity significantly inhibited cell proliferation of CMT cells.
Taken together, the findings indicated that KMO is a potential biomarker for tumor diagnosis, and this might open up new perspectives for clinical applications of CMT.
American Psychological Association (APA)
Chiu, Yi-Han& Lei, Han-Jung& Huang, Kuo-Chin& Chiang, Yi-Lin& Lin, Chen-Si. 2019. Overexpression of Kynurenine 3-Monooxygenase Correlates with Cancer Malignancy and Predicts Poor Prognosis in Canine Mammary Gland Tumors. Journal of Oncology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184406
Modern Language Association (MLA)
Chiu, Yi-Han…[et al.]. Overexpression of Kynurenine 3-Monooxygenase Correlates with Cancer Malignancy and Predicts Poor Prognosis in Canine Mammary Gland Tumors. Journal of Oncology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1184406
American Medical Association (AMA)
Chiu, Yi-Han& Lei, Han-Jung& Huang, Kuo-Chin& Chiang, Yi-Lin& Lin, Chen-Si. Overexpression of Kynurenine 3-Monooxygenase Correlates with Cancer Malignancy and Predicts Poor Prognosis in Canine Mammary Gland Tumors. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184406