SOX9 Stem-Cell Factor: Clinical and Functional Relevance in Cancer
Joint Authors
Aguilar-Medina, Maribel
Ramos-Payán, Rosalío
Ruiz-Garcia, Erika
Avendaño-Félix, Mariana
Lizárraga-Verdugo, Erik
Bermúdez, Mercedes
Romero-Quintana, José Geovanni
López-Camarillo, César
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-01
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Transcriptional and epigenetic embryonic programs can be reactivated in cancer cells.
As result, a specific subset of undifferentiated cells with stem-cells properties emerges and drives tumorigenesis.
Recent findings have shown that ectoderm- and endoderm-derived tissues continue expressing stem-cells related transcription factors of the SOX-family of proteins such as SOX2 and SOX9 which have been implicated in the presence of cancer stem-like cells (CSCs) in tumors.
Currently, there is enough evidence suggesting an oncogenic role for SOX9 in different types of human cancers.
This review provides a summary of the current knowledge about the involvement of SOX9 in development and progression of cancer.
Understanding the functional roles of SOX9 and clinical relevance is crucial for developing novel treatments targeting CSCs in cancer.
American Psychological Association (APA)
Aguilar-Medina, Maribel& Avendaño-Félix, Mariana& Lizárraga-Verdugo, Erik& Bermúdez, Mercedes& Romero-Quintana, José Geovanni& Ramos-Payán, Rosalío…[et al.]. 2019. SOX9 Stem-Cell Factor: Clinical and Functional Relevance in Cancer. Journal of Oncology،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1184452
Modern Language Association (MLA)
Aguilar-Medina, Maribel…[et al.]. SOX9 Stem-Cell Factor: Clinical and Functional Relevance in Cancer. Journal of Oncology No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1184452
American Medical Association (AMA)
Aguilar-Medina, Maribel& Avendaño-Félix, Mariana& Lizárraga-Verdugo, Erik& Bermúdez, Mercedes& Romero-Quintana, José Geovanni& Ramos-Payán, Rosalío…[et al.]. SOX9 Stem-Cell Factor: Clinical and Functional Relevance in Cancer. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1184452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184452