Accuracy of mRNA HPV Tests for Triage of Precursor Lesions and Cervical Cancer: A Systematic Review and Meta-Analysis
Joint Authors
Rosa, Maria Ines
Macedo, Ana Cristina L.
Gonçalves, João Carlos N.
Bavaresco, Daniela Vicente
Grande, Antonio José
Chiaramonte Silva, Napoleão
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objective.
This systematic review evaluates the accuracy of the mRNA HPV biomarker in cervical smears to identify cervical intraepithelial neoplasia (CIN) 2 or 3 and cervical cancer.
Data Source.
Eligible studies were identified by performing a search of electronic databases on Medline via Pubmed, Lilacs, Cochrane Library, Embase, and Grey literature for papers published between January 1990 and June 2018.
Study Eligibility Criteria.
As no randomized studies were identified, this review focuses on observational studies in which the mRNA HPV diagnostic test was compared to a histopathology reference standard.
We analyzed studies that included women screened for cervical cancer using mRNA HPV.
Study Appraisal and Synthesis Methods.
After screening, 61 studies including 29,674 patients met the inclusion criteria and were analyzed.
Dichotomization was performed by defining CIN2 or worse (CIN2+) versus CIN1, HPV infection, and normal (CIN 1-).
The analysis was discriminated by the following tests: Aptima, PreTect HPV Profeer, NucliSens EasyQ HPV, OncoTect, and Quantivirus.
Results.
Analyzing by technique, Aptima, with 28 studies, exhibited superior performance, showing for the outcomes CIN2+ and CIN3+ an AUC of 0.88 (0.82-0.95) and 0.91 (0.84-0.99), a pooled sensitivity of 92.8% (95%CI 91.9-93.7) and 95.6% (95%CI 94.5-96.5), and a pooled specificity of 60.5% (95%CI 59.8-61.3) and 61.9% (95%CI 61.1-62.7), respectively.
Conclusion.
This study supports the current hypothesis that the mRNA HPV assay is an adequate tool for secondary cervical cancer screening.
American Psychological Association (APA)
Macedo, Ana Cristina L.& Gonçalves, João Carlos N.& Bavaresco, Daniela Vicente& Grande, Antonio José& Chiaramonte Silva, Napoleão& Rosa, Maria Ines. 2019. Accuracy of mRNA HPV Tests for Triage of Precursor Lesions and Cervical Cancer: A Systematic Review and Meta-Analysis. Journal of Oncology،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1184458
Modern Language Association (MLA)
Macedo, Ana Cristina L.…[et al.]. Accuracy of mRNA HPV Tests for Triage of Precursor Lesions and Cervical Cancer: A Systematic Review and Meta-Analysis. Journal of Oncology No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1184458
American Medical Association (AMA)
Macedo, Ana Cristina L.& Gonçalves, João Carlos N.& Bavaresco, Daniela Vicente& Grande, Antonio José& Chiaramonte Silva, Napoleão& Rosa, Maria Ines. Accuracy of mRNA HPV Tests for Triage of Precursor Lesions and Cervical Cancer: A Systematic Review and Meta-Analysis. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1184458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184458