lncRNA SNHG5 Modulates Endometrial Cancer Progression via the miR-25-3pBTG2 Axis
Joint Authors
Shan, Baoen
Li, Shi
Shan, Yanan
Li, Xiaoya
Zhang, Cong
Wei, Sisi
Dai, Suli
Zhao, Riyang
Zhao, Xiwa
Zhao, Lianmei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Endometrial carcinoma (EC) is one of the most common malignancies of the female genital tract, although the mechanisms of EC initiation and development remain incompletely understood.
In this study, we demonstrated that the noncoding RNA SNHG5 can inhibit the proliferation, migration, and invasion of EC cells by suppressing the expression of its putative target miR-25-3p.
Overexpression of miR-25-3p significantly promoted the proliferation, migration, and invasion of EC cells.
In addition, we showed that miR-25-3p represses the expression of BTG2 by directly binding to the 3′-UTR of BTG2 mRNA.
Furthermore, increased miR-25-3p expression and decreased SNHG5 and BTG2 expression were observed in EC tissues, and the expression of SNHG5 was negatively correlated to that of miR-25-3p but positively correlated to that of BTG2.
In summary, for the first time, we report that the SNHG5/miR-25-3p/BTG2 axis plays an important role in EC progression and is of great potential clinical significance for EC diagnosis and therapy.
American Psychological Association (APA)
Li, Shi& Shan, Yanan& Li, Xiaoya& Zhang, Cong& Wei, Sisi& Dai, Suli…[et al.]. 2019. lncRNA SNHG5 Modulates Endometrial Cancer Progression via the miR-25-3pBTG2 Axis. Journal of Oncology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184461
Modern Language Association (MLA)
Li, Shi…[et al.]. lncRNA SNHG5 Modulates Endometrial Cancer Progression via the miR-25-3pBTG2 Axis. Journal of Oncology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1184461
American Medical Association (AMA)
Li, Shi& Shan, Yanan& Li, Xiaoya& Zhang, Cong& Wei, Sisi& Dai, Suli…[et al.]. lncRNA SNHG5 Modulates Endometrial Cancer Progression via the miR-25-3pBTG2 Axis. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1184461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184461