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Current and Emerging Targets in Immunotherapy for Osteosarcoma
Joint Authors
Tsuchiya, Hiroyuki
Yamamoto, Norio
Takeuchi, Akihiko
Miwa, Shinji
Shirai, Toshiharu
Hayashi, Katsuhiro
Igarashi, Kentaro
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Osteosarcoma is the most common primary malignancy of bone.
Although outcomes of patients with osteosarcoma have improved since the introduction of chemotherapy, outcomes of metastatic or unresectable osteosarcomas are still unsatisfactory.
To improve osteosarcoma outcomes, the development of novel systemic therapies for osteosarcoma is needed.
Since the 1880s, various immunotherapies have been utilized in patients with osteosarcoma and some patients have shown response to the treatment.
Based on recent studies about the role of the immune system in malignancies, immunotherapies including immune modulators such as interleukin-2 and muramyl tripeptide, dendritic cells, immune checkpoint inhibitors, and engineered T cells have been utilized in patients with malignancies.
Although there are limited reports of immunotherapies for osteosarcoma, immunotherapy is thought to be a promising treatment option for treating osteosarcomas.
In this review, an overview of various immunotherapies for osteosarcoma is provided and their potential as adjuvant therapies is discussed.
American Psychological Association (APA)
Miwa, Shinji& Shirai, Toshiharu& Yamamoto, Norio& Hayashi, Katsuhiro& Takeuchi, Akihiko& Igarashi, Kentaro…[et al.]. 2019. Current and Emerging Targets in Immunotherapy for Osteosarcoma. Journal of Oncology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1184467
Modern Language Association (MLA)
Miwa, Shinji…[et al.]. Current and Emerging Targets in Immunotherapy for Osteosarcoma. Journal of Oncology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1184467
American Medical Association (AMA)
Miwa, Shinji& Shirai, Toshiharu& Yamamoto, Norio& Hayashi, Katsuhiro& Takeuchi, Akihiko& Igarashi, Kentaro…[et al.]. Current and Emerging Targets in Immunotherapy for Osteosarcoma. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1184467
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184467