Molecular Age-Related Changes in the Anterior Segment of the Eye

Joint Authors

Hernández-Zimbrón, Luis Fernando
Gonzalez-Salinas, Roberto
Gulias-Cañizo, Rosario
Golzarri, María F.
Martínez-Báez, Blanca Elizabeth
Quiroz-Mercado, Hugo

Source

Journal of Ophthalmology

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-09-24

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Purpose.

To examine the current knowledge about the age-related processes in the anterior segment of the eye at a biological, clinical, and molecular level.

Methods.

We reviewed the available published literature that addresses the aging process of the anterior segment of the eye and its associated molecular and physiological events.

We performed a search on PubMed, CINAHL, and Embase using the MeSH terms “eye,” “anterior segment,” and “age.” We generated searches to account for synonyms of these keywords and MESH headings as follows: (1) “Eye” AND “ageing process” OR “anterior segment ageing” and (2) “Anterior segment” AND “ageing process” OR “anterior segment” AND “molecular changes” AND “age.” Results.

Among the principal causes of age-dependent alterations in the anterior segment of the eye, we found the mutation of the TGF-β gene and loss of autophagy in addition to oxidative stress, which contributes to the pathogenesis of degenerative diseases.

Conclusions.

In this review, we summarize the current knowledge regarding some of the molecular mechanisms related to aging in the anterior segment of the eye.

We also introduce and propose potential roles of autophagy, an important mechanism responsible for maintaining homeostasis and proteostasis under stress conditions in the anterior segment during aging.

American Psychological Association (APA)

Hernández-Zimbrón, Luis Fernando& Gulias-Cañizo, Rosario& Golzarri, María F.& Martínez-Báez, Blanca Elizabeth& Quiroz-Mercado, Hugo& Gonzalez-Salinas, Roberto. 2017. Molecular Age-Related Changes in the Anterior Segment of the Eye. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1184481

Modern Language Association (MLA)

Hernández-Zimbrón, Luis Fernando…[et al.]. Molecular Age-Related Changes in the Anterior Segment of the Eye. Journal of Ophthalmology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1184481

American Medical Association (AMA)

Hernández-Zimbrón, Luis Fernando& Gulias-Cañizo, Rosario& Golzarri, María F.& Martínez-Báez, Blanca Elizabeth& Quiroz-Mercado, Hugo& Gonzalez-Salinas, Roberto. Molecular Age-Related Changes in the Anterior Segment of the Eye. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1184481

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1184481