Minimally Invasive Repetitive UVA Irradiation along with Riboflavin Treatment Increased the Strength of Sclera Collagen Cross-Linking
Joint Authors
Chu, Yanhua
Han, Quanhong
Xiao, Bo
Wang, Hongyan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
This study aimed to investigate the efficacy of minimally invasive repetitive UVA irradiation along with riboflavin treatment on sclera collagen cross-linking in rabbits.
Method.
Forty-eight healthy adult New Zealand white rabbits were randomly divided into four groups: pseudosurgery group (group I), single-irradiation group (group II), duplicate-irradiation group (group III), and triplicate-irradiation group (group IV), with 12 rabbits in each group.
For the single-irradiation group, a specially made LED light source was inserted through a minimally invasive conjunctival incision to gain close contact with the sclera for irradiation, and for the repetitive irradiation groups, the above experimental procedure was repeated once or twice every other week.
Biomechanical parameters of the sclera including ultimate stress (σ) and 8% Young’s modulus (E) were compared among the groups.
Results.
In comparison with control group I, the ultimate stress of group II, group III, and group IV increased by 80.1%, 107.9%, and 182.1%, respectively, and their 8% Young’s modulus increased by 106.1%, 159.5%, and 208.5%, respectively, one day after surgery (P<0.01).
Conclusion.
Repetitive minimally invasive UVA irradiation with riboflavin significantly increased biomechanical strength of the sclera in the irradiated area, and biomechanical strength increased with repeated times of irradiation.
American Psychological Association (APA)
Xiao, Bo& Chu, Yanhua& Wang, Hongyan& Han, Quanhong. 2017. Minimally Invasive Repetitive UVA Irradiation along with Riboflavin Treatment Increased the Strength of Sclera Collagen Cross-Linking. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1184491
Modern Language Association (MLA)
Xiao, Bo…[et al.]. Minimally Invasive Repetitive UVA Irradiation along with Riboflavin Treatment Increased the Strength of Sclera Collagen Cross-Linking. Journal of Ophthalmology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1184491
American Medical Association (AMA)
Xiao, Bo& Chu, Yanhua& Wang, Hongyan& Han, Quanhong. Minimally Invasive Repetitive UVA Irradiation along with Riboflavin Treatment Increased the Strength of Sclera Collagen Cross-Linking. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1184491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184491