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Inflammatory Biomarkers as Predictors of Response to Immunotherapy in Urological Tumors
Joint Authors
Gurioli, Giorgia
De Giorgi, Ugo
Brighi, N.
Schepisi, Giuseppe
Cursano, Maria Concetta
Ravaglia, Giorgia
Altavilla, Amelia
Burgio, Salvatore Luca
Testoni, Sara
Menna, Cecilia
Farolfi, Alberto
Casadei, Chiara
Tonini, Giuseppe
Santini, Daniele
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Immunotherapy represents the new era of cancer treatment because of its promising results in various cancer types.
In urological tumors, the use of the immune-checkpoint inhibitors (ICIs) is increasingly spreading.
Although not all patients and not all diseases respond equally well to immunotherapy, there is an increasing need to find predictive markers of response to ICIs.
Patient- and tumor-related factors may be involved in primary and secondary resistance to immunotherapy: tumor-derived protein and cytokines, tumor mutational burden, and patient performance status and comorbidities can condition tumor response to ICIs.
Recently, some of these factors have been evaluated as potential biomarkers of response, with conflicting results.
To date, the expression of programmed death-ligand 1 (PD-L1) and the presence of deficient mismatch repair (dMMR) in tumor tissue are the only biomarkers capable of guiding the clinician’s decision in urothelial cancer and prostate cancer, respectively.
In this review, we performed a comprehensive search of the main publications on biomarkers that are predictive of response to ICIs in urological cancers.
Our aim was to understand whether existing data have the potential to drive clinical decision-making in the near future.
American Psychological Association (APA)
Schepisi, Giuseppe& Brighi, N.& Cursano, Maria Concetta& Gurioli, Giorgia& Ravaglia, Giorgia& Altavilla, Amelia…[et al.]. 2019. Inflammatory Biomarkers as Predictors of Response to Immunotherapy in Urological Tumors. Journal of Oncology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184498
Modern Language Association (MLA)
Schepisi, Giuseppe…[et al.]. Inflammatory Biomarkers as Predictors of Response to Immunotherapy in Urological Tumors. Journal of Oncology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1184498
American Medical Association (AMA)
Schepisi, Giuseppe& Brighi, N.& Cursano, Maria Concetta& Gurioli, Giorgia& Ravaglia, Giorgia& Altavilla, Amelia…[et al.]. Inflammatory Biomarkers as Predictors of Response to Immunotherapy in Urological Tumors. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184498