Ki-67 Expression is a Significant Prognostic Factor Only When Progesterone Receptor Expression is Low in Estrogen Receptor-Positive and HER2-Negative Early Breast Cancer
Joint Authors
Kang, Young-Joon
Han, Jaihong
Lee, Han-Byoel
Kim, Yun Gyoung
Kim, Yumi
Yoo, Tae-Kyung
Lee, Eun-Shin
Moon, Hyeong-Gon
Noh, Dong-Young
Han, Wonshik
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
While the value of Ki-67 has been recognized in breast cancer, controversy also exists.
The goal of this study is to show the prognostic value of Ki-67 according to progesterone receptor (PgR) expression in patients who have estrogen receptor- (ER-) positive, human epidermal growth factor receptor 2- (HER2-) negative early breast cancer.
Methods.
The records of nonmetastatic invasive breast cancer patients who underwent surgery at a single institution between 2009 and 2012 were reviewed.
Primary end point was recurrence-free survival (RFS), and secondary end point was overall survival (OS).
Ki-67 and PgR were assessed with immunohistochemistry for the tumor after surgery.
Results.
A total of 1848 patients were enrolled in this study.
223 (12%) patients had high (≥10%) Ki-67, and 1625 (88%) had low Ki-67 expression.
Significantly worse RFS and OS were observed in the high vs.
low Ki-67 expression only when the PgR was low (<20%) (p<0.001 and 0.005, respectively, for RFS and OS).
There was no significant difference in RFS and OS according to Ki-67 when the PgR was high (p=0.120 and 0.076).
RFS of four groups according to high/low Ki-67 and PgR expression was compared.
The low PgR and high Ki-67 expression group showed worst outcome among them (p<0.001).
In a multivariate analysis, high Ki-67 was an independent prognostic factor when the PgR was low (HR 3.05; 95% CI 1.50–6.19; p=0.002).
Conclusions.
Ki-67 had a value as a prognostic factor only under low PgR expression level in early breast cancer.
PgR should be considered in evaluating the prognosis of breast cancer patients using Ki-67.
American Psychological Association (APA)
Kang, Young-Joon& Lee, Han-Byoel& Kim, Yun Gyoung& Han, Jaihong& Kim, Yumi& Yoo, Tae-Kyung…[et al.]. 2019. Ki-67 Expression is a Significant Prognostic Factor Only When Progesterone Receptor Expression is Low in Estrogen Receptor-Positive and HER2-Negative Early Breast Cancer. Journal of Oncology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1184507
Modern Language Association (MLA)
Kang, Young-Joon…[et al.]. Ki-67 Expression is a Significant Prognostic Factor Only When Progesterone Receptor Expression is Low in Estrogen Receptor-Positive and HER2-Negative Early Breast Cancer. Journal of Oncology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1184507
American Medical Association (AMA)
Kang, Young-Joon& Lee, Han-Byoel& Kim, Yun Gyoung& Han, Jaihong& Kim, Yumi& Yoo, Tae-Kyung…[et al.]. Ki-67 Expression is a Significant Prognostic Factor Only When Progesterone Receptor Expression is Low in Estrogen Receptor-Positive and HER2-Negative Early Breast Cancer. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1184507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184507