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Development of Poly LacticGlycolic Acid (PLGA) Microspheres for Controlled Release of Rho-Associated Kinase Inhibitor
Joint Authors
Koda, Sho
Okumura, Naoki
Kitano, Junji
Koizumi, Noriko
Tabata, Yasuhiko
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
The purpose of this study was to investigate the feasibility of poly lactic/glycolic acid (PLGA) as a drug delivery carrier of Rho kinase (ROCK) inhibitor for the treatment of corneal endothelial disease.
Method.
ROCK inhibitor Y-27632 and PLGA were dissolved in water with or without gelatin (W1), and a double emulsion [(W1/O)/W2] was formed with dichloromethane (O) and polyvinyl alcohol (W2).
Drug release curve was obtained by evaluating the released Y-27632 by using high performance liquid chromatography.
PLGA was injected into the anterior chamber or subconjunctiva in rabbit eyes, and ocular complication was evaluated by slitlamp microscope and histological analysis.
Results.
Y-27632 incorporated PLGA microspheres with different molecular weights, and different composition ratios of lactic acid and glycolic acid were fabricated.
A high molecular weight and low content of glycolic acid produced a slower and longer release.
The Y-27632 released from PLGA microspheres significantly promoted the cell proliferation of cultured corneal endothelial cells.
The injection of PLGA did not induce any evident eye complication.
Conclusions.
ROCK inhibitor-incorporated PLGA microspheres were fabricated, and the microspheres achieved the sustained release of ROCK inhibitor over 7–10 days in vitro.
Our data should encourage researchers to use PLGA microspheres for treating corneal endothelial diseases.
American Psychological Association (APA)
Koda, Sho& Okumura, Naoki& Kitano, Junji& Koizumi, Noriko& Tabata, Yasuhiko. 2017. Development of Poly LacticGlycolic Acid (PLGA) Microspheres for Controlled Release of Rho-Associated Kinase Inhibitor. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1184524
Modern Language Association (MLA)
Koda, Sho…[et al.]. Development of Poly LacticGlycolic Acid (PLGA) Microspheres for Controlled Release of Rho-Associated Kinase Inhibitor. Journal of Ophthalmology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1184524
American Medical Association (AMA)
Koda, Sho& Okumura, Naoki& Kitano, Junji& Koizumi, Noriko& Tabata, Yasuhiko. Development of Poly LacticGlycolic Acid (PLGA) Microspheres for Controlled Release of Rho-Associated Kinase Inhibitor. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1184524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184524