![](/images/graphics-bg.png)
IL-2 Induces Transient Arrest in the G1 Phase to Protect Cervical Cancer Cells from Entering Apoptosis
Joint Authors
Rocha-Zavaleta, Leticia
Valle-Mendiola, Arturo
Gutiérrez-Hoya, Adriana
Lagunas-Cruz, María del Carmen
Weiss-Steider, Benny
Soto-Cruz, Isabel
Trejo-Huerta, Jonathan
Mora-García, María de Lourdes
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Interleukin 2 (IL-2) has been used for the treatment of different types of cancer that express the IL-2 receptor (IL-2R).
However, the effect of IL-2 on cervical cancer cells is unknown.
IL-2R is present in normal cells of the immune system but not in the healthy cervix.
We report that IL-2R is expressed in cervical cancer cells.
IL-2 decreases cervical cancer cell proliferation via transient arrest of the G1 phase, which does not result in apoptosis or senescence.
IL-2 upregulates the expression of p53 and p21 and downregulates cyclin D.
In addition, we report the resistance of cervical cancer cells to treatments that induce apoptosis in HeLa and INBL cells.
When arrested cells were treated with cisplatin, the cytokine protected cells from apoptosis induced by cisplatin.
The effects of IL-2 on the cell cycle do not induce cellular senescence or activate the proapoptotic protein Bax.
The cell arrest induced by IL-2 is conferring protection to cells against apoptosis.
American Psychological Association (APA)
Lagunas-Cruz, María del Carmen& Valle-Mendiola, Arturo& Trejo-Huerta, Jonathan& Rocha-Zavaleta, Leticia& Mora-García, María de Lourdes& Gutiérrez-Hoya, Adriana…[et al.]. 2019. IL-2 Induces Transient Arrest in the G1 Phase to Protect Cervical Cancer Cells from Entering Apoptosis. Journal of Oncology،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1184526
Modern Language Association (MLA)
Lagunas-Cruz, María del Carmen…[et al.]. IL-2 Induces Transient Arrest in the G1 Phase to Protect Cervical Cancer Cells from Entering Apoptosis. Journal of Oncology No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1184526
American Medical Association (AMA)
Lagunas-Cruz, María del Carmen& Valle-Mendiola, Arturo& Trejo-Huerta, Jonathan& Rocha-Zavaleta, Leticia& Mora-García, María de Lourdes& Gutiérrez-Hoya, Adriana…[et al.]. IL-2 Induces Transient Arrest in the G1 Phase to Protect Cervical Cancer Cells from Entering Apoptosis. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1184526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184526