Advances in Molecular Mechanisms and Immunotherapy Involving the Immune Cell-Promoted Epithelial-to-Mesenchymal Transition in Lung Cancer
Joint Authors
Bronte, Giuseppe
Martinelli, Giovanni
De Matteis, Serena
Canale, Matteo
Verlicchi, Alberto
Delmonte, Angelo
Crinò, Lucio
Ulivi, Paola
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Immunotherapy has offered a new opportunity for the treatment of many malignancies.
In patients with lung cancer, immune checkpoint inhibitors have significantly improved survival.
However, little is known about predictive factors or primary and acquired resistance mechanisms.
Epithelial-to-mesenchymal transition (EMT) is a complex of phenotypic changes involved in carcinogenesis and resistance to cancer treatments.
Specifically, immune cells in the tumor microenvironment can promote EMT, and mesenchymal phenotype acquisition negatively regulates the anticancer immune response.
EMT is associated with higher expression of PD-L1 and other immune checkpoints.
In this review, we focused on the role of EMT in the interplay between tumor cells and the immune system, with particular emphasis on lung cancer.
On the basis of our findings, we hypothesize that the effects of EMT on immune cells could be overcome in this disease by a new combination of immune checkpoint inhibitors.
American Psychological Association (APA)
De Matteis, Serena& Canale, Matteo& Verlicchi, Alberto& Bronte, Giuseppe& Delmonte, Angelo& Crinò, Lucio…[et al.]. 2019. Advances in Molecular Mechanisms and Immunotherapy Involving the Immune Cell-Promoted Epithelial-to-Mesenchymal Transition in Lung Cancer. Journal of Oncology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184528
Modern Language Association (MLA)
De Matteis, Serena…[et al.]. Advances in Molecular Mechanisms and Immunotherapy Involving the Immune Cell-Promoted Epithelial-to-Mesenchymal Transition in Lung Cancer. Journal of Oncology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1184528
American Medical Association (AMA)
De Matteis, Serena& Canale, Matteo& Verlicchi, Alberto& Bronte, Giuseppe& Delmonte, Angelo& Crinò, Lucio…[et al.]. Advances in Molecular Mechanisms and Immunotherapy Involving the Immune Cell-Promoted Epithelial-to-Mesenchymal Transition in Lung Cancer. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184528