The Protective Effect of Dietary Phytosterols on Cancer Risk: A Systematic Meta-Analysis
Joint Authors
Jiang, Lu
Zhao, Xin
Xu, Jun
Li, Chujun
Yu, Yue
Wang, Wei
Zhu, Lingjun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Backgrounds/Aims.
Many studies have explored the association between dietary phytosterols and cancer risk, but the results have been inconsistent.
We aimed to provide a synopsis of the current understanding of phytosterol intake for cancer risk through a systematic evaluation of the results from previous studies.
Methods.
We performed a literature search of PUBMED, EMBASE, CNKI, and Wanfang, and studies published before May 2019 focusing on dietary total phytosterols, β-sitosterol, campesterol, stigmasterol, β-sitostanol, and campestanol, as well as their relationships with cancer risk, were included in this meta-analysis.
Summaries of the relative risks from 11 case-control and case-cohort studies were eventually estimated by randomized or fixed effects models.
Results.
The summary relative risk for the highest versus the lowest intake was 0.63 (95% confidence interval [CI] = 0.49–0.81) for total phytosterols, 0.74 (95% CI = 0.54–1.02) for β-sitosterol, 0.72 (95% CI = 0.51–1.00) for campesterol, 0.83 (95% CI = 0.60–1.16) for stigmasterol, 1.12 (95% CI = 0.96–1.32) for β-sitostanol, and 0.77 (95% CI = 0.65–0.90) for campestanol.
In a dose-response analysis, the results suggested a linear association for campesterol and a nonlinear association for total phytosterol intake.
Conclusion.
Our findings support the hypothesis that high phytosterol intake is inversely related to risk of cancer.
Further studies with prospective designs that control for vital confounders and investigate the important anticancer effects of dietary phytosterols are warranted.
American Psychological Association (APA)
Jiang, Lu& Zhao, Xin& Xu, Jun& Li, Chujun& Yu, Yue& Wang, Wei…[et al.]. 2019. The Protective Effect of Dietary Phytosterols on Cancer Risk: A Systematic Meta-Analysis. Journal of Oncology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184531
Modern Language Association (MLA)
Jiang, Lu…[et al.]. The Protective Effect of Dietary Phytosterols on Cancer Risk: A Systematic Meta-Analysis. Journal of Oncology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1184531
American Medical Association (AMA)
Jiang, Lu& Zhao, Xin& Xu, Jun& Li, Chujun& Yu, Yue& Wang, Wei…[et al.]. The Protective Effect of Dietary Phytosterols on Cancer Risk: A Systematic Meta-Analysis. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1184531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184531