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Diverse Effects of Lysophosphatidic Acid Receptors on Ovarian Cancer Signaling Pathways
Joint Authors
Onallah, Hadil
Davidson, Ben
Reich, Reuven
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Lysophosphatidic acid (LPA) is a bioactive phospholipid with mitogenic and growth factor-like activities affecting cell invasion, cancer progression, and resistance.
It is produced mainly by autotaxin and acts on six G-protein-coupled receptors, LPAR1-6.
LPA has recently been implicated as a growth factor present in ascites of ovarian cancer patients.
However, mitogenic pathways stimulated by LPA via its receptors may involve any novel, thus far uncharacterized, signaling pathway(s).
Here we show that three LPA receptors are involved in tumor progression by activation of both the AKT and ERK signaling pathways.
CRISPR-edited LPAR2 and LPAR3 knockouts have opposing effects on ERK activation, whereas LPAR6 is involved in the activation of AKT, affecting cell migration and invasion.
Our study identifies specific molecular machinery triggered by LPA and its receptors that modulates tumor cells and can serve as therapeutic target in this malignancy.
American Psychological Association (APA)
Onallah, Hadil& Davidson, Ben& Reich, Reuven. 2019. Diverse Effects of Lysophosphatidic Acid Receptors on Ovarian Cancer Signaling Pathways. Journal of Oncology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184534
Modern Language Association (MLA)
Onallah, Hadil…[et al.]. Diverse Effects of Lysophosphatidic Acid Receptors on Ovarian Cancer Signaling Pathways. Journal of Oncology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1184534
American Medical Association (AMA)
Onallah, Hadil& Davidson, Ben& Reich, Reuven. Diverse Effects of Lysophosphatidic Acid Receptors on Ovarian Cancer Signaling Pathways. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184534