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Asymmetric Outcomes of Type 1 Retinopathy of Prematurity after Bilateral Intravitreal Ranibizumab Treatment
Joint Authors
Zhao, Peiquan
Ji, Xunda
Xu, Yu
Lv, Jiao
Zhang, Qi
Fei, Ping
Peng, Jie
Li, Yi-an
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To present cases with retinopathy of prematurity (ROP), who were treated with intravitreal injection of ranibizumab (IVR) and had unpredictable asymmetric outcomes.
Methods.
A retrospective review was performed in infants with type 1 ROP and had bilateral IVR (0.25 mg/0.025 mL) as initial treatment.
Patients were classified into the asymmetric outcome group and the symmetric outcome group.
Results.
Eighty-four patients (168 eyes) were included.
There were 18 eyes of 9 patients (10.7%) in the asymmetric outcome group and 150 eyes of 75 patients (89.3%) in the symmetric outcome group.
In the symmetric outcome group, 86 eyes (57.3%) had ROP regression, 60 eyes (40%) had reactivation requiring laser treatment, and 4 eyes (2.7%) progressed to retinal detachment requiring vitrectomy.
In the asymmetric outcome group, one of the eyes of the 9 patients had ROP regression with/without reactivation after IVR, while the contralateral eyes had negative response, including remarkable posterior fibrosis, partial or total retinal detachment, and vitreous hemorrhage.
There was statistically significant difference between the birth weight of the two groups.
Conclusion.
Contralateral eyes with ROP can take a different clinical course after ranibizumab treatment.
High rate of reactivation after IVR is another concern that ophthalmologists should pay attention to.
American Psychological Association (APA)
Lv, Jiao& Zhang, Qi& Xu, Yu& Ji, Xunda& Fei, Ping& Peng, Jie…[et al.]. 2017. Asymmetric Outcomes of Type 1 Retinopathy of Prematurity after Bilateral Intravitreal Ranibizumab Treatment. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1184554
Modern Language Association (MLA)
Lv, Jiao…[et al.]. Asymmetric Outcomes of Type 1 Retinopathy of Prematurity after Bilateral Intravitreal Ranibizumab Treatment. Journal of Ophthalmology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1184554
American Medical Association (AMA)
Lv, Jiao& Zhang, Qi& Xu, Yu& Ji, Xunda& Fei, Ping& Peng, Jie…[et al.]. Asymmetric Outcomes of Type 1 Retinopathy of Prematurity after Bilateral Intravitreal Ranibizumab Treatment. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1184554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184554