Outcome of Surgical Treatment in Late-Onset Capsular Block Syndrome

Abstract EN

Purpose.

To further investigate the pathogenesis of late-onset capsular block syndrome (CBS) and to evaluate the safety of surgical treatment.

Methods.

Seven patients diagnosed with late-onset CBS were retrospectively analyzed.

Anterior chamber depth (ACD), intraocular pressure (IOP), refractive diopter, and best-corrected visual acuity (BCVA) before and after surgery were recorded.

The opaque substance was tested with Western blot, and a flow cytometer multiple array assay system was utilized to evaluate the levels of inflammatory cytokines from opaque substance and aqueous humor, respectively.

Results.

Patients who had undergone surgical treatment showed a significant BCVA and spherical equivalent refractive error improvement (P=0.002, P=0.021, resp.).

Nevertheless, ACD and IOP before and after surgery were in normal range with no difference (P=0.165, P=0.749, resp.).

αB-crystallin and βB-crystallin were detected in all opaque substances.

Tumor necrosis factor-alpha (TNF-α) and interlukin-1β (IL-1β) levels in opaque substance were significantly higher than those in aqueous humor (P=0.038, P=0.007, resp.), while IL-2 and IL-6 were not detected in any samples.

Conclusions.

Opaque substance is derived from human lens epithelial cells.

Inflammatory cytokines may be involved in the pathogenesis of late-onset CBS.

In addition, surgical treatment is an effective approach.

This trial is registered with ChiCTR-IOR-17011287.