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Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells?
Joint Authors
Tax, Gábor
Lia, Andrea
Santino, Angelo
Roversi, Pietro
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-01
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Endoplasmic reticulum glycoprotein folding quality control (ERQC) and ER-associated degradation (ERAD) preside over cellular glycoprotein secretion and maintain steady glycoproteostasis.
When cells turn malignant, cancer cell plasticity is affected and supported either by point mutations, preferential isoform selection, altered expression levels, or shifts to conformational equilibria of a secreted glycoprotein.
Such changes are crucial in mediating altered extracellular signalling, metabolic behavior, and adhesion properties of cancer cells.
It is therefore conceivable that interference with ERQC and/or ERAD can be used to selectively damage cancers.
Indeed, inhibitors of the late stages of ERAD are already in the clinic against cancers such as multiple myeloma.
Here, we review recent advances in our understanding of the complex relationship between glycoproteostasis and cancer biology and discuss the potential of ERQC and ERAD modulators for the selective targeting of cancer cell plasticity.
American Psychological Association (APA)
Tax, Gábor& Lia, Andrea& Santino, Angelo& Roversi, Pietro. 2019. Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells?. Journal of Oncology،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1184573
Modern Language Association (MLA)
Tax, Gábor…[et al.]. Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells?. Journal of Oncology No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1184573
American Medical Association (AMA)
Tax, Gábor& Lia, Andrea& Santino, Angelo& Roversi, Pietro. Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells?. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1184573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184573