Exosomal miRNA: Small Molecules, Big Impact in Colorectal Cancer
Joint Authors
Aubin, François
Garrido, Carmen
Vautrot, Valentin
Chanteloup, Gaëtan
Elmallah, Mohammed
Cordonnier, Marine
Gobbo, Jessica
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-13
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Colorectal cancer (CRC) is one of the major causes of cancer-related deaths worldwide.
Tumor microenvironment (TME) contains many cell types including stromal cells, immune cells, and endothelial cells.
The TME modulation explains the heterogeneity of response to therapy observed in patients.
In this context, exosomes are emerging as major contributors in cancer biology.
Indeed, exosomes are implicated in tumor proliferation, angiogenesis, invasion, and premetastatic niche formation.
They contain bioactive molecules such as proteins, lipids, and RNAs.
More recently, many studies on exosomes have focused on miRNAs, small noncoding RNA molecules able to influence protein expression.
In this review, we describe miRNAs transported by exosomes in the context of CRC and discuss their influence on TME and their potential as circulating biomarkers.
This overview underlines emerging roles for exosomal miRNAs in cancer research for the near future.
American Psychological Association (APA)
Vautrot, Valentin& Chanteloup, Gaëtan& Elmallah, Mohammed& Cordonnier, Marine& Aubin, François& Garrido, Carmen…[et al.]. 2019. Exosomal miRNA: Small Molecules, Big Impact in Colorectal Cancer. Journal of Oncology،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1184595
Modern Language Association (MLA)
Vautrot, Valentin…[et al.]. Exosomal miRNA: Small Molecules, Big Impact in Colorectal Cancer. Journal of Oncology No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1184595
American Medical Association (AMA)
Vautrot, Valentin& Chanteloup, Gaëtan& Elmallah, Mohammed& Cordonnier, Marine& Aubin, François& Garrido, Carmen…[et al.]. Exosomal miRNA: Small Molecules, Big Impact in Colorectal Cancer. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1184595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184595