AURKA rs8173 G>C Polymorphism Decreases Wilms Tumor Risk in Chinese Children
Joint Authors
Zhu, Jinhong
He, Jing
Xia, Huimin
Liu, Jiabin
Fu, Wen
Liu, Guo-Chang
Lu, Tongyi
Li, Li
Lin, Ao
Zhang, Tiesong
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Wilms tumor is the most common type of renal malignancy in children.
Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) in the AURKA gene could predispose to several human malignancies.
We recruited 145 cases and 531 cancer-free controls to investigate whether AURKA gene variants modify Wilms tumor susceptibility.
Three AURKA SNPs (rs1047972 C>T, rs2273535 T>A, and rs8173 G>C) were genotyped by the Taqman methodology.
Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of association between AURKA SNPs and Wilms tumor risk.
We found that only the rs8173 G>C polymorphism was significantly associated with Wilms tumor risk (GC vs.
GG: adjusted OR (AOR) = 0.50, 95% CI = 0.35–0.73, P=0.0002; GC/CC vs.
GG: AOR = 0.60, 95% CI = 0.42–0.88, P=0.008).
Stratification analysis revealed that rs8173 GC/CC genotypes were associated with Wilms tumor risk among children aged >18 months (AOR = 0.56, 95% CI = 0.34–0.93, P=0.024), male children (AOR = 0.54, 95% CI = 0.33–0.90, P=0.017), and children with clinical stage III + IV diseases (AOR = 0.56, 95% CI = 0.35–0.90, P=0.017).
Haplotype analysis indicated that the CAG haplotype was significantly associated with increased Wilms tumor risk.
In conclusion, our findings indicated that the AURKA rs8173 G>C polymorphism was associated with decreased Wilms tumor risk in Chinese children.
American Psychological Association (APA)
Lu, Tongyi& Li, Li& Zhu, Jinhong& Liu, Jiabin& Lin, Ao& Fu, Wen…[et al.]. 2019. AURKA rs8173 G>C Polymorphism Decreases Wilms Tumor Risk in Chinese Children. Journal of Oncology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1184667
Modern Language Association (MLA)
Lu, Tongyi…[et al.]. AURKA rs8173 G>C Polymorphism Decreases Wilms Tumor Risk in Chinese Children. Journal of Oncology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1184667
American Medical Association (AMA)
Lu, Tongyi& Li, Li& Zhu, Jinhong& Liu, Jiabin& Lin, Ao& Fu, Wen…[et al.]. AURKA rs8173 G>C Polymorphism Decreases Wilms Tumor Risk in Chinese Children. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1184667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184667