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Immunomodulatory Effect after Irreversible Electroporation in Patients with Locally Advanced Pancreatic Cancer
Joint Authors
Wang, Jun
He, Chaobin
Sun, Shuxin
Zhang, Yu
Li, Shengping
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Purpose.
Irreversible electroporation (IRE) has been demonstrated to be a safe and effective method for locally advanced pancreatic cancer (LAPC).
The aim of this study was to evaluate the immunomodulatory effect after IRE and to evaluate the prognostic value of variations of the immune parameters in LAPC patients after IRE.
Methods.
Peripheral blood samples of 34 patients were obtained preoperatively and on the third day (D3) and seventh day (D7) after IRE, respectively.
The phenotypes of lymphocytes were analyzed by flow cytometry, and dynamic changes of serum levels of cytokines, complement, and immunoglobulin were assayed by enzyme-linked immunosorbent assay.
Receiver operating characteristic (ROC) curve and concordance index (C-index) were used to compare the survival predictive ability.
Results.
There was a transitory decrease followed by a steady increase for CD4+ T cell, CD8+ T cell, NK cell, IL-2, C3, C4, and IgG while a reverse trend was detected for Treg cell, IL-6, and IL10 after IRE.
The alteration of CD8+ T cell between D3 and D7 was identified as a prognostic factor for both overall survival (OS) and progression-free survival (PFS).
The values of ROC curve (AUC) and C-indexes of the alteration of CD8+ T cell for OS and PFS were 0.816 and 0.773 and 0.816 and 0.639, respectively, which were larger than those of other immune or inflammation-based indexes.
Conclusions.
This study presented the first evidence of IRE-based immunomodulatory in patients with LAPC.
The alteration of CD8+ T cell between D3 and D7 showed relatively good performance and could be used as an effective tool for prognostic evaluation for LAPC patients after IRE.
American Psychological Association (APA)
He, Chaobin& Wang, Jun& Sun, Shuxin& Zhang, Yu& Li, Shengping. 2019. Immunomodulatory Effect after Irreversible Electroporation in Patients with Locally Advanced Pancreatic Cancer. Journal of Oncology،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1184703
Modern Language Association (MLA)
He, Chaobin…[et al.]. Immunomodulatory Effect after Irreversible Electroporation in Patients with Locally Advanced Pancreatic Cancer. Journal of Oncology No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1184703
American Medical Association (AMA)
He, Chaobin& Wang, Jun& Sun, Shuxin& Zhang, Yu& Li, Shengping. Immunomodulatory Effect after Irreversible Electroporation in Patients with Locally Advanced Pancreatic Cancer. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1184703
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184703