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Circular RNA hsa_circ_0007142 Is Upregulated and Targets miR-103a-2-5p in Colorectal Cancer
Joint Authors
Zhu, Chang-li
Sha, Xiaofeng
Wang, Yuan
Li, Jin
Zhang, Men-yan
Guo, Zhong-ying
Sun, Su-an
He, Jing-dong
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Circular RNAs (circRNAs) are a large class of endogenous noncoding RNAs that regulate gene expression and mainly function as microRNA sponges.
This study aimed to explore the aberrant expression of circRNAs in colorectal cancer (CRC).
Using a circRNA microarray, we identified 892 differentially expressed circRNAs between six pairs of CRC and adjacent paracancerous tissues.
Among them, hsa_circ_0007142 was significantly upregulated.
Further analysis in 50 CRC clinical samples revealed that hsa_circ_0007142 upregulation was associated with poor differentiation and lymphatic metastasis of CRC.
Bioinformatic analysis and luciferase reporter assay showed that hsa_circ_0007142 targeted miR-103a-2-5p in CRC cells.
Moreover, the silencing of hsa_circ_0007142 by siRNAs decreased the proliferation, migration, and invasion of HT-29 and HCT-116 cells.
Taken together, these findings suggest that hsa_circ_0007142 is upregulated in CRC and targets miR-103a-2-5p to promote CRC.
American Psychological Association (APA)
Zhu, Chang-li& Sha, Xiaofeng& Wang, Yuan& Li, Jin& Zhang, Men-yan& Guo, Zhong-ying…[et al.]. 2019. Circular RNA hsa_circ_0007142 Is Upregulated and Targets miR-103a-2-5p in Colorectal Cancer. Journal of Oncology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184768
Modern Language Association (MLA)
Zhu, Chang-li…[et al.]. Circular RNA hsa_circ_0007142 Is Upregulated and Targets miR-103a-2-5p in Colorectal Cancer. Journal of Oncology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1184768
American Medical Association (AMA)
Zhu, Chang-li& Sha, Xiaofeng& Wang, Yuan& Li, Jin& Zhang, Men-yan& Guo, Zhong-ying…[et al.]. Circular RNA hsa_circ_0007142 Is Upregulated and Targets miR-103a-2-5p in Colorectal Cancer. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1184768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184768