Modeling Chronic Dacryocystitis in Rabbits by Nasolacrimal Duct Obstruction with Self-Curing Resin
Joint Authors
Hou, Kai
Ai, Tao
Xiang, Nan
Jin, Jing
Luo, Ban
Liu, Rong
Hu, Wei-Kun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We established a chronic dacryocystitis model by injecting of 0.05, 0.1, and 0.15 ml self-curing resin via the lacrimal punctum in rabbits.
Animals were randomized into four groups (n=11 animals/group).
The control group received 0.15 ml normal saline.
Within three months postinjection, epiphora and eye discharge were observed.
At the 90th day postlacrimal passage irrigation, CT dacryocystography was performed to find changes in the lacrimal image, and hematoxylin and eosin staining was made to identify pathological changes of the lacrimal sac.
Three months postinjection, the rabbits in control group and those who received 0.05 and 0.1 ml self-curing resin failed to develop chronic dacryocystitis.
However, 8/11 (72.7%) rabbits those received 0.15 ml self-curing resin were symptomatic and showed complete reflux in lacrimal passage irrigation, indicating the obstruction of the nasolacrimal duct.
CT dacryocystography showed that the obstruction was present only in the animals with chronic dacryocystitis.
Pathological examinations of chronic dacryocystitis also revealed significantly inflammatory changes, such as mucus epithelium thickening, irregular papillary proliferation, and submucosal fibrous deposition.
Local injection of 0.15 ml self-curing resin can induce permanent obstruction of the nasolacrimal duct in rabbits and establish a model of chronic dacryocystitis.
American Psychological Association (APA)
Hou, Kai& Ai, Tao& Liu, Rong& Xiang, Nan& Jin, Jing& Hu, Wei-Kun…[et al.]. 2017. Modeling Chronic Dacryocystitis in Rabbits by Nasolacrimal Duct Obstruction with Self-Curing Resin. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1184770
Modern Language Association (MLA)
Hou, Kai…[et al.]. Modeling Chronic Dacryocystitis in Rabbits by Nasolacrimal Duct Obstruction with Self-Curing Resin. Journal of Ophthalmology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1184770
American Medical Association (AMA)
Hou, Kai& Ai, Tao& Liu, Rong& Xiang, Nan& Jin, Jing& Hu, Wei-Kun…[et al.]. Modeling Chronic Dacryocystitis in Rabbits by Nasolacrimal Duct Obstruction with Self-Curing Resin. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1184770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184770