Sensitivity, Specificity, and Limitations of Optical Coherence Tomography Angiography in Diagnosis of Polypoidal Choroidal Vasculopathy
Joint Authors
Huang, Yi-Ming
Hsieh, Ming-Hung
Li, An-Fei
Chen, Shih-Jen
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To evaluate the sensitivity and specificity of optical coherence tomography angiography (OCTA) in differentiating polypoidal choroidal vasculopathy (PCV) from age-related macular degeneration (AMD).
Methods.
Fundus color photographs, spectral-domain optical coherence tomography, and fluorescein angiography (step 1) and OCTA (step 2) of 50 eyes that had PCV or AMD were presented to two ophthalmologists.
The final diagnoses of PCV were masked.
Sensitivity and specificity were calculated and compared to the 2-step approach (before and after OCTA) in detecting PCV.
The limitations were also evaluated.
Results.
Of the 50 eyes, 31 were PCV and 19 were non-PCV.
The sensitivity increased from 69.5% to 90% after OCTA; however, there was no significant improvement in specificity after OCTA.
70.9% of the eyes with PCV had clear or obvious branching vascular nets (BVNs) in OCTA with high sensitivity (97.5%) after OCTA.
Contrarily, 29.1% had insignificant BVNs with a low sensitivity (72.5%) after OCTA.
27% of the occult choroidal neovascularization (CNV) cases were overdiagnosed as PCV when OCTA was applied.
Conclusions.
OCTA based on clear BVNs at the choroidal level increased sensitivity of diagnosis of PCV by 20%.
However, the false-positive rate also increased in occult CNV.
Several limitations for a correct diagnosis of PCV were noted.
American Psychological Association (APA)
Huang, Yi-Ming& Hsieh, Ming-Hung& Li, An-Fei& Chen, Shih-Jen. 2017. Sensitivity, Specificity, and Limitations of Optical Coherence Tomography Angiography in Diagnosis of Polypoidal Choroidal Vasculopathy. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1184784
Modern Language Association (MLA)
Huang, Yi-Ming…[et al.]. Sensitivity, Specificity, and Limitations of Optical Coherence Tomography Angiography in Diagnosis of Polypoidal Choroidal Vasculopathy. Journal of Ophthalmology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1184784
American Medical Association (AMA)
Huang, Yi-Ming& Hsieh, Ming-Hung& Li, An-Fei& Chen, Shih-Jen. Sensitivity, Specificity, and Limitations of Optical Coherence Tomography Angiography in Diagnosis of Polypoidal Choroidal Vasculopathy. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1184784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184784