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Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved Tafluprost
Joint Authors
Tokuda, Naoto
Kitaoka, Yasushi
Matsuzawa, Akiko
Sakae, Shinsuke
Takagi, Hitoshi
Tsukamoto, Ayaka
Sase, Kana
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
The aim of the present study was to examine the effects of switching from Latanoprost ophthalmic solution containing a preservative to preservative-free Tafluprost ophthalmic solution or Tafluprost containing a preservative on ocular surfaces.
Materials and Methods.
Forty patients (40 eyes) with glaucoma (mean age: 62.0 ± 10.9 years) using Latanoprost with preservative for six months or longer were assigned either to a Tafluprost-containing-preservative group (20 eyes) or preservative-free-Tafluprost group (20 eyes).
The intraocular pressure, corneal epithelial barrier function (fluorescein uptake concentration with fluorophotometer FL-500), superficial punctate keratopathy (AD classification), and tear film breakup time (TBUT) were assessed before switching and at 12 weeks after switching.
Results.
No significant differences in intraocular pressure were noted after switching in either group.
Corneal epithelial barrier function was improved significantly after switching in both the Tafluprost-containing-preservative and the preservative-free-Tafluprost groups.
There were no significant differences in AD scores after switching in the Tafluprost-containing-preservative group, but significant improvements were noted in the preservative-free-Tafluprost group.
No significant differences in TBUT were noted in the Tafluprost-containing-preservative or preservative-free-Tafluprost groups after switching.
Conclusion.
After switching from preservative Latanoprost to Tafluprost containing-preservative or preservative-free Tafluprost, corneal epithelial barrier function was improved while the intraocular pressure reduction was retained.
American Psychological Association (APA)
Tokuda, Naoto& Kitaoka, Yasushi& Matsuzawa, Akiko& Tsukamoto, Ayaka& Sase, Kana& Sakae, Shinsuke…[et al.]. 2017. Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved Tafluprost. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1184806
Modern Language Association (MLA)
Tokuda, Naoto…[et al.]. Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved Tafluprost. Journal of Ophthalmology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1184806
American Medical Association (AMA)
Tokuda, Naoto& Kitaoka, Yasushi& Matsuzawa, Akiko& Tsukamoto, Ayaka& Sase, Kana& Sakae, Shinsuke…[et al.]. Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved Tafluprost. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1184806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184806