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Correlation of Macular Focal Electroretinogram with Ellipsoid Zone Extension in Stargardt Disease
Joint Authors
Piccardi, M.
Minnella, A. M.
Falsini, B.
Bertelli, M.
Abed, Edoardo
Placidi, Giorgio
Calandriello, Luigi
Campagna, Francesca
Savastano, Maria Cristina
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Stargardt disease (STGD1) is the most common cause of inherited juvenile macular degeneration.
This disease is characterized by a progressive accumulation of lipofuscin in the outer retina and subsequent loss of photoreceptors and retinal pigment epithelium.
The aim of this study was to evaluate the relationship between cone photoreceptor function and structure in STGD1.
Macular function was assessed by visual acuity measurement and focal electroretinogram (FERG) recording while spectral domain optical coherence tomography (SD-OCT) imaging was performed to evaluate the integrity of photoreceptors.
FERG amplitude was significantly reduced in patients with Stargardt disease (p<0.0001).
The amplitude of FERG showed a negative relationship with interruption of ellipsoid zone (EZ) (R2=0.54, p<0.0001) and a positive correlation with average macular thickness (AMT).
Conversely, visual acuity was only weakly correlated with central macular thickness (CMT) (R2=0.12, p=0.04).
In conclusion, this study demonstrates that FERG amplitude is a reliable indicator of macular cone function while visual acuity reflects the activity of the foveal region.
A precise assessment of macular cone function by FERG recording may be useful to monitor the progression of STGD1 and to select the optimal candidates to include in future clinical trials to treat this disease.
American Psychological Association (APA)
Abed, Edoardo& Placidi, Giorgio& Calandriello, Luigi& Piccardi, M.& Campagna, Francesca& Bertelli, M.…[et al.]. 2017. Correlation of Macular Focal Electroretinogram with Ellipsoid Zone Extension in Stargardt Disease. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1184827
Modern Language Association (MLA)
Abed, Edoardo…[et al.]. Correlation of Macular Focal Electroretinogram with Ellipsoid Zone Extension in Stargardt Disease. Journal of Ophthalmology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1184827
American Medical Association (AMA)
Abed, Edoardo& Placidi, Giorgio& Calandriello, Luigi& Piccardi, M.& Campagna, Francesca& Bertelli, M.…[et al.]. Correlation of Macular Focal Electroretinogram with Ellipsoid Zone Extension in Stargardt Disease. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1184827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184827