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The Protective Role of Hyaluronic Acid in Cr(VI)-Induced Oxidative Damage in Corneal Epithelial Cells
Joint Authors
Xia, Hai-Ling
Lou, Jian-Lin
Ying, Shibo
Chen, Tianhui
Feng, Lingfang
Zhang, Yixiao
Li, Tao
Wu, Wei
Jiang, Hua
Guo, Xinnian
Wang, Yu
Chen, Riping
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cr(VI) exposure could produce kinds of intermediates and reactive oxygen species, both of which were related to DNA damage.
Hyaluronan (HA) has impressive biological functions and was reported to protect corneal epithelial cells against oxidative damage induced by ultraviolet B, benzalkonium chloride, and sodium lauryl sulfate.
So the aim of our study was to investigate HA protection on human corneal epithelial (HCE) cells against Cr(VI)-induced toxic effects.
The HCE cell lines were exposed to different concentrations of K2Cr2O7 (1.875, 3.75, 7.5, 15.0, and 30 μM) or a combination of K2Cr2O7 and 0.2% HA and incubated with different times (15 min, 30 min, and 60 min).
Our data showed that Cr(VI) exposure could cause decreased cell viability, increased DNA damage, and ROS generation to the HCE cell lines.
But incubation of HA increased HCE cell survival rates and decreased DNA damage and ROS generation induced by Cr(VI) in a dose- and time-dependent manner.
We report for the first time that HA can protect HCE cells against the toxicity of Cr(VI), indicating that it will be a promising therapeutic agent to corneal injuries caused by Cr(VI).
American Psychological Association (APA)
Wu, Wei& Jiang, Hua& Guo, Xinnian& Wang, Yu& Ying, Shibo& Feng, Lingfang…[et al.]. 2017. The Protective Role of Hyaluronic Acid in Cr(VI)-Induced Oxidative Damage in Corneal Epithelial Cells. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1184830
Modern Language Association (MLA)
Wu, Wei…[et al.]. The Protective Role of Hyaluronic Acid in Cr(VI)-Induced Oxidative Damage in Corneal Epithelial Cells. Journal of Ophthalmology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1184830
American Medical Association (AMA)
Wu, Wei& Jiang, Hua& Guo, Xinnian& Wang, Yu& Ying, Shibo& Feng, Lingfang…[et al.]. The Protective Role of Hyaluronic Acid in Cr(VI)-Induced Oxidative Damage in Corneal Epithelial Cells. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1184830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184830