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Changes in Retinal Function and Cellular Remodeling Following Experimental Retinal Detachment in a Rabbit Model
Joint Authors
Barliya, Tilda
Ofri, Ron
Sandalon, Shai
Livnat, Tami
Weinberger, Dov
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Purpose.
To explore functional electroretinographic (ERG) changes and associated cellular remodeling following experimental retinal detachment in a rabbit model.
Methods.
Retinal detachment was created in ten rabbits by injecting 0.1 ml balanced salt solution under the retina.
Fundus imaging was performed 0, 3, 7, 14, and 21 days postoperatively.
ERGs were recorded pre- and 7 and 21 days postoperatively.
Eyes were harvested on day 21 and evaluated immunohistochemically (IHC) for remodeling of second- and third-order neurons.
Results.
Retinal reattachment occurred within two weeks following surgery.
No attenuation was observed in the photopic or scotopic a- and b-waves.
A secondary wavefront on the descending slope of the scotopic b-wave was the only ERG result that was attenuated in detached retinas.
IHC demonstrated anatomical changes in both ON and OFF bipolar cells.
Bassoon staining was observed in the remodeled dendrites.
Amacrine and horizontal cells did not alter, but Muller cells were clearly reactive with marked extension.
Conclusion.
Retinal detachment and reattachment were associated with functional and anatomical changes.
Exploring the significance of the secondary scotopic wavefront and its association with the remodeling of 2nd- and 3rd-order neurons will shade more light on functional changes and recovery of the retina.
American Psychological Association (APA)
Barliya, Tilda& Ofri, Ron& Sandalon, Shai& Weinberger, Dov& Livnat, Tami. 2017. Changes in Retinal Function and Cellular Remodeling Following Experimental Retinal Detachment in a Rabbit Model. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1184862
Modern Language Association (MLA)
Barliya, Tilda…[et al.]. Changes in Retinal Function and Cellular Remodeling Following Experimental Retinal Detachment in a Rabbit Model. Journal of Ophthalmology No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1184862
American Medical Association (AMA)
Barliya, Tilda& Ofri, Ron& Sandalon, Shai& Weinberger, Dov& Livnat, Tami. Changes in Retinal Function and Cellular Remodeling Following Experimental Retinal Detachment in a Rabbit Model. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1184862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184862