Anti-Inflammatory Effects of Essential Oils of Amomum aromaticum Fruits in Lipopolysaccharide-Stimulated RAW264.7 Cells
Joint Authors
Dang, Nguyen Hai
Dat, Nguyen Tien
Anh, Le Thi Van
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-25
Country of Publication
Egypt
No. of Pages
5
Abstract EN
Inflammation is a vital physiologic response of cellular injury, infection, or autoimmune activation.
Overproduction of proinflammatory mediators may result in the chronic inflammation that leads to many diseases such as rheumatoid arthritis, asthma, multiple sclerosis, and atherosclerosis.
In this study, we assessed for the first time the anti-inflammatory effects of the essential oils of Amomum aromaticum fruits (AAE) in RAW264.7 murine macrophage model.
As a result, AAE potently inhibited the production of nitric oxide in LPS-induced RAW264.7 cells with the IC50 value of 0.45 ± 0.11 μg/ml.
AAE also dose-dependently reduced the expression of two proinflammatory proteins iNOS and COX-2 in the stimulated cells.
Phytochemical analysis revealed that major compositions of the volatile oils including 1,8 cineole (48.22%), geranial (9.24%), neral (6.72%), α-pinene (2.43%), and α-terpineol (2.28%) may contribute greatly to the inhibition effects due to their anti-inflammatory properties.
The results suggest for the potential uses of AAE in chronic inflammation prevention.
American Psychological Association (APA)
Dang, Nguyen Hai& Anh, Le Thi Van& Dat, Nguyen Tien. 2020. Anti-Inflammatory Effects of Essential Oils of Amomum aromaticum Fruits in Lipopolysaccharide-Stimulated RAW264.7 Cells. Journal of Food Quality،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1184871
Modern Language Association (MLA)
Dang, Nguyen Hai…[et al.]. Anti-Inflammatory Effects of Essential Oils of Amomum aromaticum Fruits in Lipopolysaccharide-Stimulated RAW264.7 Cells. Journal of Food Quality No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1184871
American Medical Association (AMA)
Dang, Nguyen Hai& Anh, Le Thi Van& Dat, Nguyen Tien. Anti-Inflammatory Effects of Essential Oils of Amomum aromaticum Fruits in Lipopolysaccharide-Stimulated RAW264.7 Cells. Journal of Food Quality. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1184871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184871