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Effects of Bitter Melon Saponin on the Glucose and Lipid Metabolism in HepG2 Cell and C. elegans
Joint Authors
Dong, Ying
Zhu, Ying
Zhang, Yi
Xiao, Xiang
Li, Jie
Bai, Juan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-24
Country of Publication
Egypt
No. of Pages
9
Abstract EN
This study tried to explore how saponins from bitter melon (BMS) affect the glucose and lipid metabolism in palmitic acid-treated HepG2 cell and glucose-treated Caenorhabditis elegans (C.
elegans).
Results showed that BMS could effectively accelerate glucose consumption and elevate the levels of glycogen and ATP in palmitic acid-treated HepG2 cell, while significantly decreasing the triglyceride (TG) content.
qRT-PCR data indicated that BMS might promote fatty acid β-oxidation by AMPK-ACC2-CPT1 pathway and glucose uptake by upregulating GLUT4 expression.
In the model of glucose-treated C.
elegans, we observed that BMS obviously inhibited fat accumulation, along with no toxicity towards some physical activities.
The potential mechanism of BMS in the metabolism involved the suppression of synthesis of polyunsaturated fatty acids and enhancement of fatty acid β-oxidation.
Taken together, BMS exhibited ability of regulating energy metabolism in HepG2 cell line and C.
elegans.
American Psychological Association (APA)
Bai, Juan& Zhu, Ying& Li, Jie& Zhang, Yi& Dong, Ying& Xiao, Xiang. 2020. Effects of Bitter Melon Saponin on the Glucose and Lipid Metabolism in HepG2 Cell and C. elegans. Journal of Food Quality،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1184949
Modern Language Association (MLA)
Bai, Juan…[et al.]. Effects of Bitter Melon Saponin on the Glucose and Lipid Metabolism in HepG2 Cell and C. elegans. Journal of Food Quality No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1184949
American Medical Association (AMA)
Bai, Juan& Zhu, Ying& Li, Jie& Zhang, Yi& Dong, Ying& Xiao, Xiang. Effects of Bitter Melon Saponin on the Glucose and Lipid Metabolism in HepG2 Cell and C. elegans. Journal of Food Quality. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1184949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184949