Effect of MT3 on Retinal and Choroidal TGF-β2 and HAS2 Expressions in Form Deprivation Myopia of Guinea Pig
Joint Authors
Li, Bing
Li, Tao
Zhou, Xiaodong
Jiang, Bo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To confirm its dose-dependent effect on form deprivation myopia and evaluate the effect of MT3 at different tissue concentrations on changes in mRNA and protein expression for TGF-β2 and HAS2.
Methods.
MT3 was intravitreally injected into deprived eyes at two-day intervals.
Refraction was measured by streak retinoscopy after cycloplegia.
The axial dimensions were measured by A-scan ultrasound.
The quantitative RT-PCR and Western blot were used to detect the changes of TGF-β2 and HAS2 expressions in the retina and choroid of guinea pigs.
Results.
MT3 treatment produced a significant dose-dependent reduction in relative myopia compared to FD group (both p<0.001).
There were statistically significant increases in retinal and choroidal mRNA levels for both TGF-β2 and HAS2 after injections of 10 μM of MT3, when compared to the FD group.
There were no significant differences in retinal and choroidal TGF-β2 protein expression levels between the MT3 treatment groups and FD group (all p>0.05).
The injections of 10 μM of MT3 caused a marked decrease in retinal HAS2 protein expression level, when compared to the FD group (p=0.001).
Conclusion.
MT3 can inhibit form deprivation myopia, and MT3 treatment can result in changes of retinal and choroidal TGF-β2 and HAS2 mRNA and protein expressions.
American Psychological Association (APA)
Li, Tao& Zhou, Xiaodong& Li, Bing& Jiang, Bo. 2017. Effect of MT3 on Retinal and Choroidal TGF-β2 and HAS2 Expressions in Form Deprivation Myopia of Guinea Pig. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1184999
Modern Language Association (MLA)
Li, Tao…[et al.]. Effect of MT3 on Retinal and Choroidal TGF-β2 and HAS2 Expressions in Form Deprivation Myopia of Guinea Pig. Journal of Ophthalmology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1184999
American Medical Association (AMA)
Li, Tao& Zhou, Xiaodong& Li, Bing& Jiang, Bo. Effect of MT3 on Retinal and Choroidal TGF-β2 and HAS2 Expressions in Form Deprivation Myopia of Guinea Pig. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1184999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1184999