Suppression of Retinal Neovascularization by Inhibition of Galectin-1 in a Murine Model of Oxygen-Induced Retinopathy
Joint Authors
Yang, Ning
Zhang, Wenxi
He, Tao
Xing, Yiqiao
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Galectin-1 (Gal-1) has been proved to be an important factor in the process of tumor angiogenesis recently.
As a small molecule, OTX008 serves as a selective inhibitor of Gal-1.
In this study, the role of Gal-1 and the antiangiogenic effect of OTX008 on retinal neovascularization (RNV) were investigated using a mouse model of oxygen-induced retinopathy.
The outcome indicated that Gal-1 was overexpressed and closely related to retinal neovessels in OIR.
After intravitreal injection of OTX008 at P12, the RNV was significantly reduced at P17, measuring by cross-sectional H&E staining and whole-mount fluorescence.
Our results demonstrate the inhibitory function of OTX008 on RNV, which provides a promising strategy of treating retinal angiogenic diseases such as retinopathy of prematurity and proliferative diabetic retinopathy.
American Psychological Association (APA)
Yang, Ning& Zhang, Wenxi& He, Tao& Xing, Yiqiao. 2017. Suppression of Retinal Neovascularization by Inhibition of Galectin-1 in a Murine Model of Oxygen-Induced Retinopathy. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1185002
Modern Language Association (MLA)
Yang, Ning…[et al.]. Suppression of Retinal Neovascularization by Inhibition of Galectin-1 in a Murine Model of Oxygen-Induced Retinopathy. Journal of Ophthalmology No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1185002
American Medical Association (AMA)
Yang, Ning& Zhang, Wenxi& He, Tao& Xing, Yiqiao. Suppression of Retinal Neovascularization by Inhibition of Galectin-1 in a Murine Model of Oxygen-Induced Retinopathy. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1185002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185002