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Familial Retinoblastoma: Raised Awareness Improves Early Diagnosis and Outcome
Joint Authors
Al-Nawaiseh, Ibrahim
Ghanem, Aseel Q.
Yousef, Yacoub A.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
To study the impact of awareness of retinoblastoma in the affected families on the management and outcome of familial retinoblastoma patients.
Methods and Materials.
This is a retrospective, clinical case series of 44 patients with familial retinoblastoma.
Collected data included patient’s demographics, laterality, family history, age at diagnosis, presenting signs, treatment modalities, tumor stage, eye salvage rate, metastasis, and mortality.
Results.
Out of 200 retinoblastoma patients in our registry, 44 (22%) patients were familial, 18 were probands, and 26 were second, third, or fourth affected family members.
There were 76 affected eyes: 31 eyes of probands and 45 eyes of the other affected family members.
Among probands, all patients (100%) had at least one eye enucleated: 58% (18 eyes) of the affected eyes were enucleated and 32% (10 eyes) of the affected eyes were radiated.
On the other hand, among the nonprobands, only 20% had one eye enucleated, and only 4 eyes (9%) received radiation.
The eye salvage rate was significantly higher in the nonprobands than in the probands in this series (p=0.00206).
Patients diagnosed by screening (38%) had excellent visual outcome, and both eyes were salvaged.
Conclusion.
Awareness of families of the possibility of retinoblastoma and adequate screening led to a significantly higher rate of eye salvage in patients with familial retinoblastoma.
American Psychological Association (APA)
Al-Nawaiseh, Ibrahim& Ghanem, Aseel Q.& Yousef, Yacoub A.. 2017. Familial Retinoblastoma: Raised Awareness Improves Early Diagnosis and Outcome. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1185007
Modern Language Association (MLA)
Al-Nawaiseh, Ibrahim…[et al.]. Familial Retinoblastoma: Raised Awareness Improves Early Diagnosis and Outcome. Journal of Ophthalmology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1185007
American Medical Association (AMA)
Al-Nawaiseh, Ibrahim& Ghanem, Aseel Q.& Yousef, Yacoub A.. Familial Retinoblastoma: Raised Awareness Improves Early Diagnosis and Outcome. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1185007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185007