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Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy
Joint Authors
Garcia-Martin, Elena
Satue, Maria
Polo, Vicente
Rodrigo, Maria J.
Vilades, Elisa
Cipres, Marta
Melchor, Isabel
Gil-Arribas, Laura
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes.
Methods.
Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy controls underwent retinal evaluation using Spectralis optical coherence tomography.
Macular ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) were evaluated.
Peripapillary RNFL thickness was assessed using Glaucoma and Axonal Analytics applications.
Comparison between patients with the presence/absence of systemic vascular complications and different disease duration was made.
Results.
Macular GCL was reduced in patients compared to controls (p<0.001).
Differences in the macular RNFL thickness were only observed in the outer inferior sector (p=0.033).
A reduction in the peripapillary RNFL (average, inferior, and inferotemporal thickness, p<0.05 for all three) was observed in patients using both applications.
Patients with chronic systemic vascular complications presented a reduction in the temporal RNFL (p=0.019) compared to patients without complications.
The superotemporal RNFL thickness was thinner in patients with longer disease duration.
Conclusions.
Patients with type 2 DM without diabetic retinopathy and good metabolic control present neurodegeneration affecting neurons in the macular area and axons in different sectors of the optic disc.
Systemic vascular complications contributed to further axonal damage in these patients, suggesting a possible role of subclinical ischaemia to retinal neurodegeneration in type 2 DM.
American Psychological Association (APA)
Garcia-Martin, Elena& Cipres, Marta& Melchor, Isabel& Gil-Arribas, Laura& Vilades, Elisa& Polo, Vicente…[et al.]. 2019. Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy. Journal of Ophthalmology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1185144
Modern Language Association (MLA)
Garcia-Martin, Elena…[et al.]. Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy. Journal of Ophthalmology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1185144
American Medical Association (AMA)
Garcia-Martin, Elena& Cipres, Marta& Melchor, Isabel& Gil-Arribas, Laura& Vilades, Elisa& Polo, Vicente…[et al.]. Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy. Journal of Ophthalmology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1185144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185144