Evaluation of Cerebrospinal Fluid Pressure by a Formula and Its Role in the Pathogenesis of Glaucoma
Joint Authors
Harris, Alon
Iester, Michele
Traverso, Carlo E.
Landi, Laura
Casciaro, Federica
Telani, Serena
Verticchio Vercellin, Alice C.
Saint, Lauren
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To investigate potential associations between intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) in patients with primary open-angle glaucoma (POAG) and healthy subjects.
Methods.
Forty-three subjects were recruited.
Weight and height were measured to calculate body mass index (BMI), along with blood pressure, heart rate, visual acuity, and IOP.
Biometrics exam, corneal pachymetry, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular thickness were assessed.
The visual field exam was performed on all patients, and both pattern standard deviation (PSD) and mean deviation (MD) were considered.
CSFP was estimated indirectly by using the mathematical formula CSFP = 0.44 × BMI + 0.16 × diastolic pressure − 0.18 × age − 1.91, based on the previous scientific studies.
The TLCPD was calculated as follows: IOP−CSFP.
Results.
A significant (p<0.05) difference was found between the two groups for several parameters.
Specifically, the CSFP was lower in patients with POAG than in healthy subjects (8.14 ± 4.52 and 7.43 ± 2.06, p<0.001, respectively).
Anamnestic TLCPD was found to be significantly (p<0.001) higher in patients with POAG compared to healthy subjects.
A significant (p<0.05) correlation was found between anamnestic TLCPD and MD (r = −0.31), inferior RNFL thickness (r = −0.29), superior RNFL thickness (r = −0.27), IOP (r = 0.22), and CSFP (r = −0.46).
Conclusion.
The CSFP was lower in glaucomatous patients compared to healthy subjects, whereas the TLCPD was higher in glaucomatous patients compared to healthy subjects, even though this difference was not statistically significant.
A higher TLCPD may damage the RNFL, resulting in functional visual field impairment.
American Psychological Association (APA)
Landi, Laura& Casciaro, Federica& Telani, Serena& Traverso, Carlo E.& Harris, Alon& Verticchio Vercellin, Alice C.…[et al.]. 2019. Evaluation of Cerebrospinal Fluid Pressure by a Formula and Its Role in the Pathogenesis of Glaucoma. Journal of Ophthalmology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1185149
Modern Language Association (MLA)
Landi, Laura…[et al.]. Evaluation of Cerebrospinal Fluid Pressure by a Formula and Its Role in the Pathogenesis of Glaucoma. Journal of Ophthalmology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1185149
American Medical Association (AMA)
Landi, Laura& Casciaro, Federica& Telani, Serena& Traverso, Carlo E.& Harris, Alon& Verticchio Vercellin, Alice C.…[et al.]. Evaluation of Cerebrospinal Fluid Pressure by a Formula and Its Role in the Pathogenesis of Glaucoma. Journal of Ophthalmology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1185149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185149