Thinner Corneas Appear to Have More Striking Effects of Corneal Collagen Crosslinking in Patients with Progressive Keratoconus

Abstract EN

Purpose.

To analyze the outcomes and difference after UVA/riboflavin corneal collagen crosslinking (CXL) in four different corneal thickness groups of patients with progressive keratoconus.

Methods.

Retrospective study.

Eyes with progressive keratoconus after CXL were divided into 4 subgroups as follows: group 1, thinnest corneal thickness (TCT) ≤ 400 µm; group 2, 400 µm < TCT ≤ 450 µm; group 3, 450 µm < TCT ≤ 500 µm; group 4, TCT ≥ 500 µm.

Baseline, 6-month, and 12-month visual acuity, corneal topography, TCT, and endothelial cell density were evaluated.

Results.

The analysis included 123 eyes of 101 patients.

At 6 and 12 months after CXL, there was a mean improvement about visual acuity and keratometry values in all patients.

There was a reduction in the change of maximum keratometry (Kmax) with the increase of TCT.

After 1 year of treatment, it was 3.04 ± 0.75 D in group 1, 2.38 ± 0.51 D in group 2, 1.57 ± 0.35 D in group 3, and 0.31 ± 0.20 D in group 4.

Conclusion.

CXL is successful in halting the progression of keratoconus and there was a negative linear correlation between TCT and Kmax.

Advanced cases of progressive keratoconus seemed to obtain more benefits from the flatting effects of CXL.