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Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients
Joint Authors
Schötzau, Andreas
Grieshaber, Matthias C.
Nützi, Christoph
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To evaluate clinically activated retinal astrocytes and Müller cells (ARAM) regarding retinal sensitivity and retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG).
Methods.
Central visual field (VF; i.e., retinal sensitivity) was measured with a custom-made macular pattern by microperimetry and correlated with the presence (ARAM+) or absence (ARAM−) of ARAM on red-free fundus photography and with the corresponding RNFL by optical coherence tomography (OCT).
Results.
In the eyes of POAG patients, ARAM+ had overall a significantly lower retinal sensitivity (ARAM+: 7.34 dB, ARAM−: 11.9 dB; p<0.001) and lower RNFL thickness in the inferior peripapillary quadrants compared to ARAM− (RNFL superior: ARAM+ 74.2 μm, ARAM− 77.5 μm; RNFL temporal: ARAM+ 46.8 μm, ARAM− 53.0 μm, p<0.001; and RNFL inferior: ARAM+ 63.2 μm, ARAM− 73.1 μm, p<0.001).
Within the same eye, ARAM+ showed a lower retinal sensitivity compared to ARAM− ([ARAM− (11.13 dB)] − [ARAM+ (9.56 dB) = 1.57 dB; p=0.25).
The proportion of ARAM+ per eye correlated strongly with reduced retinal light sensitivity (p=0.02), corresponding lower peripapillary RNFL thickness (p=0.02), and lower RNFL temporal quadrant thickness (p<0.01), but not with greater age (p=0.45).
Conclusion.
ARAM was more frequently identified in the eyes with a lower retinal sensitivity and peripapillary RNFL thickness and may be a clinical sign in the macula for an advanced stage of POAG.
American Psychological Association (APA)
Nützi, Christoph& Schötzau, Andreas& Grieshaber, Matthias C.. 2017. Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1185261
Modern Language Association (MLA)
Nützi, Christoph…[et al.]. Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients. Journal of Ophthalmology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1185261
American Medical Association (AMA)
Nützi, Christoph& Schötzau, Andreas& Grieshaber, Matthias C.. Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1185261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185261