Comparison of Progression Rate of Retinal Pigment Epithelium Loss in Patients with Neovascular Age-Related Macular Degeneration Treated with Ranibizumab and Aflibercept
Joint Authors
Wons, Juliana
Becker, Matthias D.
Michels, Stephan
Wirth, Magdalena A.
Graf, Nicole
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
Retinal pigment epithelium (RPE) loss in neovascular age-related macular degeneration (nAMD) seem to have a linear progression but might be influenced by the treatment.
The purpose of the study is the comparison of RPE loss over three years in patients treated with intravitreal ranibizumab to patients who were switched to aflibercept.
Methods.
A retrospective analysis with 96 eyes switched to aflibercept was conducted.
The progression rate of RPE loss was evaluated in patients who showed atrophy one year prior to switch (n=17) or on switch date (n=19).
The RPE loss was evaluated by spectral domain optical coherence tomography (SD-OCT).
Further, 22 eyes from patients treated with ranibizumab were compared.
Results.
The median yearly progression of RPE loss after square root transformation showed no significant difference in the year prior to switch compared to the year after switch (p=0.854).
In patients who received only ranibizumab, the median yearly progression of RPE loss was 0.15 mm/y, for aflibercept patients, 0.13 mm/y.
This difference was not statistically significant (p=0.172).
Conclusions.
There seems to be a linear progression rate of RPE loss in patients treated with ranibizumab as well as in patients with aflibercept.
No significant increase of progression rate was found after switch to aflibercept.
American Psychological Association (APA)
Wons, Juliana& Wirth, Magdalena A.& Graf, Nicole& Becker, Matthias D.& Michels, Stephan. 2017. Comparison of Progression Rate of Retinal Pigment Epithelium Loss in Patients with Neovascular Age-Related Macular Degeneration Treated with Ranibizumab and Aflibercept. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1185341
Modern Language Association (MLA)
Wons, Juliana…[et al.]. Comparison of Progression Rate of Retinal Pigment Epithelium Loss in Patients with Neovascular Age-Related Macular Degeneration Treated with Ranibizumab and Aflibercept. Journal of Ophthalmology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1185341
American Medical Association (AMA)
Wons, Juliana& Wirth, Magdalena A.& Graf, Nicole& Becker, Matthias D.& Michels, Stephan. Comparison of Progression Rate of Retinal Pigment Epithelium Loss in Patients with Neovascular Age-Related Macular Degeneration Treated with Ranibizumab and Aflibercept. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1185341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185341