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Diagnostic Ability of Retinal Nerve Fiber Layer Thickness Deviation Map for Localized and Diffuse Retinal Nerve Fiber Layer Defects
Joint Authors
Seong, Mincheol
Shin, Joong Won
Lee, Jung Wook
Hong, Eun Hee
Uhm, Ki Bang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To evaluate the diagnostic ability of the retinal nerve fiber layer (RNFL) deviation map for glaucoma with localized or diffuse RNFL defects.
Methods.
Eyes of 139 glaucoma patients and 165 healthy subjects were enrolled.
All participants were imaged with Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA, USA).
A RNFL defect was defined as at least 10 contiguous red (<1% level) superpixels in RNFL deviation map.
The area, location, and angular width of RNFL defects were automatically measured.
We compared sensitivities, specificities, and area under the receiver operating characteristic curves (AUCs) of RNFL deviation map and circumpapillary RNFL thickness for localized and diffuse RNFL defects.
Subgroup analysis was performed according to the severity of glaucoma.
Results.
For localized defects, the area of RNFL defects (AUC, 0.991; sensitivity, 97%; specificity, 90%) in deviation map showed a higher diagnostic performance (p=0.002) than the best circumpapillary RNFL parameter (inferior RNFL thickness; AUC, 0.914; sensitivity, 79%; specificity, 92%).
For diffuse defects, there was no significant difference between the RNFL deviation map and circumpapillary RNFL parameters.
In mild glaucoma with localized defect, RNFL deviation map showed a better diagnostic performance than circumpapillary RNFL measurement.
Conclusions.
RNFL deviation map is a useful tool for evaluating glaucoma regardless of localized or diffuse defect type and has advantages over circumpapillary RNFL measurement for detecting localized RNFL defects.
American Psychological Association (APA)
Shin, Joong Won& Seong, Mincheol& Lee, Jung Wook& Hong, Eun Hee& Uhm, Ki Bang. 2017. Diagnostic Ability of Retinal Nerve Fiber Layer Thickness Deviation Map for Localized and Diffuse Retinal Nerve Fiber Layer Defects. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1185481
Modern Language Association (MLA)
Shin, Joong Won…[et al.]. Diagnostic Ability of Retinal Nerve Fiber Layer Thickness Deviation Map for Localized and Diffuse Retinal Nerve Fiber Layer Defects. Journal of Ophthalmology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1185481
American Medical Association (AMA)
Shin, Joong Won& Seong, Mincheol& Lee, Jung Wook& Hong, Eun Hee& Uhm, Ki Bang. Diagnostic Ability of Retinal Nerve Fiber Layer Thickness Deviation Map for Localized and Diffuse Retinal Nerve Fiber Layer Defects. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1185481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185481