Bruch’s Membrane Opening Minimum Rim Width Measurement with SD-OCT: A Method to Correct for the Opening Size of Bruch’s Membrane

Abstract EN

A precise evaluation of the retinal nerve fiber layer thickness (RNFLT) is key for diagnosing and monitoring glaucoma.

The Bruch’s membrane opening minimum rim width (BMO-MRW) has been proposed as a reproducible assessment of the optic nerve.

The BMO-MRW measures the minimum distance from the BMO to the internal limiting membrane.

We propose an approach to correct the BMO-MRW using the BMO size for increased accuracy in interindividual comparisons in future studies.

Eighty-one healthy patients received SPECTRALIS spectral domain optical coherence tomography measurements for the peripapillary RNFLT and BMO-MRW.

We calculated a BMO size-corrected BMO-MRW using the mean BMO size of our cohort.

BMO size was defined using the manufacturer-provided BMO area and manually measured BMO perimeter.

We observed that the BMO-MRW correlated highly with the perimeter (r=−0.553, p<0.0001) and the area of the BMO (r=−0.546, p<0.0001).

Using these parameters, we provided a corrected BMO size-adjusted BMO-MRW which was better correlated with the RNFLT compared to the noncorrected one (z=−3.3495, p=0.0004).

We demonstrated the dependency of the BMO-MRW on ONH size.

Furthermore, we showed the superiority of the corrected BMO-MRW using either the manually measured optic nerve head perimeter or the automatically provided ONH for future studies.