Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective Survey
Joint Authors
Påhlson, Carl
Madsen, Kim B.
Wallménius, Katarina
Fridman, Åke
Nilsson, Kenneth
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Vector-borne diseases such as Lyme borreliosis and rickettsioses have been associated with ocular inflammation.
Our aim was to study patients with diagnosed uveitis to evaluate serological signs of infection or exposure to these tick-borne agents.
Forty-eight patients were prospectively examined with serology together with medical records and a questionnaire concerning previous exposure, diseases, and treatments.
Seven patients (14.6%) showed seroconversion to Rickettsia spp.
between acute and convalescent phase sera, which provides support for a positive Rickettsia diagnosis according to guidelines.
The specificity was confirmed by Western blot.
Additional 28 patients had stationary titres of which eight (16.6%) had 1 : 256 or higher titre in the first serum, and another 13 patients were seronegative.
No epidemiological risk factor or marker could be identified.
For Borrelia, only three patients showed moderate IgG titres.
A control group of 100 blood donors, 60 patients with rheumatic disease, and 56 patients seeking medical care were tested of which 2.0–7.1% showed low anti-Rickettsia titres and 3.0–8.3% anti-Borrelia titres.
The findings are indicative for an association between infection or exposure to Rickettsia spp.
and uveitis with a seropositivity among patients with recurrent uveitis in concordance with the spread of rickettsial exposure in a tick-exposed population.
American Psychological Association (APA)
Madsen, Kim B.& Wallménius, Katarina& Fridman, Åke& Påhlson, Carl& Nilsson, Kenneth. 2017. Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective Survey. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1185625
Modern Language Association (MLA)
Madsen, Kim B.…[et al.]. Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective Survey. Journal of Ophthalmology No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1185625
American Medical Association (AMA)
Madsen, Kim B.& Wallménius, Katarina& Fridman, Åke& Påhlson, Carl& Nilsson, Kenneth. Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective Survey. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1185625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185625