The Degeneration and Apoptosis Patterns of Cone Photoreceptors in rd11 Mice
Joint Authors
Zhang, Hua
He, Ying
Pang, Jijing
Li, Xia
Dai, Xufeng
Han, Juanjuan
Zhang, Yangyang
Qi, Yan
Liu, Yan
Chang, Bo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The retinal degeneration 11 (rd11) mouse is a new animal model with rapid photoreceptor degeneration.
The long-term efficacy of gene therapy has a direct relationship with the onset of photoreceptor degeneration or apoptosis, whereas the degeneration or apoptosis patterns of photoreceptors are still unclear in rd11 mice.
The distribution patterns of cone function-related L- and S-opsin were examined by immunofluorescence staining, and the apoptosis was performed by TUNEL assay in rd11 mice.
The expression pattern of L-opsin or S-opsin in rd11 retina at postnatal day (P) 14 was similar to the pattern observed in wildtype retina.
With increasing age, the expression of L-opsin and S-opsin, especially S-opsin, decreased significantly in rd11 mice.
The degeneration of L-opsin began around the optic nerve and expanded to the periphery of the retina, from the ventral/nasal to dorsal/temporal retina, whereas the expression of S-opsin gradually decreased from the dorsal/temporal to ventral/nasal retina.
Apoptotic signal appeared at P14 and was strongest at P28 of rd11 mice.
The key genes associated with apoptosis confirmed those changes.
These indicated that the degeneration and apoptosis of cone photoreceptors began at P14 of rd11 mice, which was a key point for gene therapy.
American Psychological Association (APA)
Zhang, Hua& Li, Xia& Dai, Xufeng& Han, Juanjuan& Zhang, Yangyang& Qi, Yan…[et al.]. 2017. The Degeneration and Apoptosis Patterns of Cone Photoreceptors in rd11 Mice. Journal of Ophthalmology،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1185712
Modern Language Association (MLA)
Zhang, Hua…[et al.]. The Degeneration and Apoptosis Patterns of Cone Photoreceptors in rd11 Mice. Journal of Ophthalmology No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1185712
American Medical Association (AMA)
Zhang, Hua& Li, Xia& Dai, Xufeng& Han, Juanjuan& Zhang, Yangyang& Qi, Yan…[et al.]. The Degeneration and Apoptosis Patterns of Cone Photoreceptors in rd11 Mice. Journal of Ophthalmology. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1185712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185712