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Oral Hyaluronic Acid Supplementation for the Treatment of Dry Eye Disease: A Pilot Study
Joint Authors
Moon, Chan Hee
Kim, Yeseul
Kim, Bo-Yeon
Jang, Sun Young
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
To evaluate the clinical efficacy of oral hyaluronic acid (HA) in patients with dry eye disease (DED).
Study Design.
Prospective randomized controlled trial.
Methods.
This trial enrolled 54 subjects and they were randomized into the study or control group.
The inclusion criteria were as follows: (1) >18 years of age; (2) distance best-corrected visual acuity ≥ 20/40 Snellen equivalent in each eye; (3) IOP ≤ 21 mmHg in both eyes; (4) ocular surface disease index (OSDI) score of ≥18 and <65; (5) <10 seconds of tear break up time (TBUT); (6) >5 corneal spots of corneal fluorescein staining (CFS); and (7) ≤ 10 mm/5 min of the Schirmer test.
All subjects were treated with a topical HA, and the study group was supplemented with oral HA.
OSDI, TBUT, CFS, and the Schirmer test were evaluated for ocular surface parameters.
Results.
24 patients were assigned in the study group.
Significant improvement of OSDI, TBUT, and CFS was observed at 1 month and 3 months after oral HA administration in the study group.
At baseline and follow-up at 1 and 3 months, OSDI scores were 61.8 ± 16.2, 47.3 ± 11.6, and 42.3 ± 9.1, respectively (P<0.001).
TBUT was improved after treatment for 1 month and 3 months (4.2 ± 1.1; P=0.005 and 4.7 ± 1.1; P<0.012).
There were also statistically significant improvements in the CSF (1.8 ± 1.0, 0.8 ± 0.7; P<0.001) at baseline compared with those at 1 month.
Conclusions.
A combined supplement of both oral and topical HA more efficiently improves corneal epithelial wound healing and related symptoms than topical HA alone, in DED.
American Psychological Association (APA)
Kim, Yeseul& Moon, Chan Hee& Kim, Bo-Yeon& Jang, Sun Young. 2019. Oral Hyaluronic Acid Supplementation for the Treatment of Dry Eye Disease: A Pilot Study. Journal of Ophthalmology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1185768
Modern Language Association (MLA)
Kim, Yeseul…[et al.]. Oral Hyaluronic Acid Supplementation for the Treatment of Dry Eye Disease: A Pilot Study. Journal of Ophthalmology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1185768
American Medical Association (AMA)
Kim, Yeseul& Moon, Chan Hee& Kim, Bo-Yeon& Jang, Sun Young. Oral Hyaluronic Acid Supplementation for the Treatment of Dry Eye Disease: A Pilot Study. Journal of Ophthalmology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1185768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1185768