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Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications
Joint Authors
Kolluru, Gopi
Cai, Meng
Ahmed, Asif
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-20
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
MicroRNAs are small, noncoding RNA molecules that regulate target gene expression in the posttranscriptional level.
Unlike siRNA, microRNAs are “fine-tuners” rather than “switches” in the regulation of gene expression; thus they play key roles in maintaining tissue homeostasis.
The aberrant microRNA expression is implicated in the disease process.
To date, numerous studies have demonstrated the regulatory roles of microRNAs in various pathophysiological conditions.
In contrast, the study of microRNA in pregnancy and its associated complications, such as preeclampsia (PE), fetal growth restriction (FGR), and preterm labor, is a young field.
Over the last decade, the knowledge of pregnancy-related microRNAs has increased and the molecular mechanisms by which microRNAs regulate pregnancy or its associated complications are emerging.
In this review, we focus on the recent advances in the research of pregnancy-related microRNAs, especially their function in pregnancy-associated complications and the potential clinical applications.
Here microRNAs that associate with pregnancy are classified as placenta-specific, placenta-associated, placenta-derived circulating, and uterine microRNA according to their localization and origin.
MicroRNAs offer a great potential for developing diagnostic and therapeutic targets in pregnancy-related disorders.
American Psychological Association (APA)
Cai, Meng& Kolluru, Gopi& Ahmed, Asif. 2017. Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications. Journal of Pregnancy،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1186089
Modern Language Association (MLA)
Cai, Meng…[et al.]. Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications. Journal of Pregnancy No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1186089
American Medical Association (AMA)
Cai, Meng& Kolluru, Gopi& Ahmed, Asif. Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications. Journal of Pregnancy. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1186089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186089