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The Efficacy of Intravitreal Conbercept for Chronic Central Serous Chorioretinopathy
Joint Authors
Mao, Jianbo
Zhang, Caiyun
Liu, Chenyi
Shen, Lijun
Lao, Jimeng
Shao, Yirun
Chen, Yiqi
Tao, Jiwei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
To evaluate the efficacy and safety of conbercept for patients with chronic central serous chorioretinopathy (CSC).
Methods.
A retrospective clinical study.
Thirty-one patients (35 eyes) with chronic CSC were given intravitreal injections of conbercept and followed up for at least 6 months.
Observed indicators included best-corrected visual acuity (BCVA), central macular thickness (CMT), and resolution of subretinal fluid (SRF).
Serial changes in BCVA and CMT were analyzed by using repeated measures analysis of variance.
Results.
During the 6-month follow-up, the mean number of injections required and performed was 1.77 ± 0.60.
The logMAR BCVA was 0.48 ± 0.26 at the baseline, 0.34 ± 0.26, 0.30 ± 0.26, 0.27 ± 0.26, 0.24 ± 0.26, and 0.23 ± 0.26 at 2-week and 1-, 2-, 3-, and 6-month follow-ups, respectively (F = 27.173, P<0.05).
CMT was 313.74 ± 144.51 μm at the baseline and decreased to 263.49 ± 120.44 μm, 225.91 ± 91.98 μm, 195.77 ± 66.69 μm, 189.74 ± 65.41 μm, and 199.49 ± 81.50 μm at 2-week and 1-, 2-, 3-, and 6-month follow-ups, respectively (F = 18.093, P<0.05).
Full resolution of SRF was achieved in 8 (22.9%) eyes at 1 month, 16 (45.7%) eyes at 2 months, 22 (62.9%) eyes at 3 months, and 27 (77.1%) eyes at 6 months after the initial treatment of anti-VEGF injection.
No severe adverse event was noted relevant to the therapy.
Conclusions.
Intravitreal injection of conbercept may effectively reduce the CMT and improve the BCVA in chronic CSC in a short term of 6 months.
American Psychological Association (APA)
Mao, Jianbo& Zhang, Caiyun& Liu, Chenyi& Shen, Lijun& Lao, Jimeng& Shao, Yirun…[et al.]. 2019. The Efficacy of Intravitreal Conbercept for Chronic Central Serous Chorioretinopathy. Journal of Ophthalmology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1186103
Modern Language Association (MLA)
Mao, Jianbo…[et al.]. The Efficacy of Intravitreal Conbercept for Chronic Central Serous Chorioretinopathy. Journal of Ophthalmology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1186103
American Medical Association (AMA)
Mao, Jianbo& Zhang, Caiyun& Liu, Chenyi& Shen, Lijun& Lao, Jimeng& Shao, Yirun…[et al.]. The Efficacy of Intravitreal Conbercept for Chronic Central Serous Chorioretinopathy. Journal of Ophthalmology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1186103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186103