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One-Year Outcomes of 1 Dose versus 3 Loading Doses Followed by Pro Re Nata Regimen Using Ranibizumab for Neovascular Age-Related Macular Degeneration: The ARTIS Trial
Joint Authors
Yuan, Yuan-zhi
Zhao, Peiquan
Wang, Fenghua
Sun, Xiaodong
Zhao, Jingke
Zhang, Qi
Qin, Guoyou
Chang, Qing
Ye, Xiaofeng
Wang, Ling
Shen, Mengxi
Xu, Ding
Zhang, Wei
Yuan, Fei
Wang, Fang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
P urpose.
To compare the functional and anatomical outcomes of one dose and three loading doses followed by the pro re nata (PRN) regimen in Chinese neovascular age-related macular degeneration (nvAMD) (including polypoidal choroidal vasculopathy (PCV)) patients.
Methods.
In this multicenter, prospective, open-label, controlled, 12-month study (ClinicalTrials.gov: NCT02810808), patients were randomized (1 : 1) to 1 dose + PRN (PRN group) or 3 loading doses + PRN (LD group) using intravitreal ranibizumab treatment.
Best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were evaluated.
The main outcome was the change in BCVA.
The noninferiority limit was 5 letters.
Results.
Forty-five patients in the PRN group and 49 patients in the LD group finished 12-month follow-up.
Each group included 4 PCV patients.
The mean change in BCVA from baseline was 7.8 letters in the PRN group, compared with 10.9 letters in the LD group (P=0.344).
There were no significant differences between two groups in the mean change of CRT (−159.3 μm vs.
−120.5 μm) at month 12.
The mean number of injections during the 12-month follow-up was 6.0 in the PRN group and 6.8 in the LD group.
The proportion of patients who gained an improvement in visual acuity by 15 or more letters was 28.9% in the PRN group and 44.9% in the LD group (P=0.066).
Conclusion.
One dose + PRN showed noninferior visual gains than 3 loading doses + PRN regimen using ranibizumab in Chinese nvAMD and PCV patients.
Number of injections in the PRN group was similar as that in the LD group but remained a potential risk of vision instability during one-year follow-up using OCT-guided retreatment criteria.
This trial is registered with NCT02810808.
American Psychological Association (APA)
Wang, Fenghua& Yuan, Yuan-zhi& Wang, Ling& Ye, Xiaofeng& Wang, Fang& Sun, Xiaodong…[et al.]. 2019. One-Year Outcomes of 1 Dose versus 3 Loading Doses Followed by Pro Re Nata Regimen Using Ranibizumab for Neovascular Age-Related Macular Degeneration: The ARTIS Trial. Journal of Ophthalmology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1186140
Modern Language Association (MLA)
Wang, Fang…[et al.]. One-Year Outcomes of 1 Dose versus 3 Loading Doses Followed by Pro Re Nata Regimen Using Ranibizumab for Neovascular Age-Related Macular Degeneration: The ARTIS Trial. Journal of Ophthalmology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1186140
American Medical Association (AMA)
Wang, Fenghua& Yuan, Yuan-zhi& Wang, Ling& Ye, Xiaofeng& Wang, Fang& Sun, Xiaodong…[et al.]. One-Year Outcomes of 1 Dose versus 3 Loading Doses Followed by Pro Re Nata Regimen Using Ranibizumab for Neovascular Age-Related Macular Degeneration: The ARTIS Trial. Journal of Ophthalmology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1186140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186140