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TLR Specific Immune Responses against Helminth Infections
Joint Authors
Rajasekaran, Sivaprakasam
Anuradha, Rajamanickam
Bethunaickan, Ramalingam
Source
Journal of Parasitology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Despite marked improvement in the quality of lives across the globe, more than 2 million individuals in socioeconomically disadvantaged environments remain infected by helminth (worm) parasites.
Owing to the longevity of the worms and paucity of immunologic controls, these parasites survive for long periods within the bloodstream, lymphatics, and gastrointestinal tract resulting in pathologic conditions such as anemia, cirrhosis, and lymphatic filariasis.
Despite infection, an asymptomatic state may be maintained by the host immunoregulatory environment, which involves multiple levels of regulatory cells and cytokines; a breakdown of this regulation is observed in pathological disease.
The role of TLR expression and function in relation to intracellular parasites has been documented but limited studies are available for multicellular helminth parasites.
In this review, we discuss the unique and shared host effector mechanisms elicited by systemic helminth parasites and their derived products, including the role of TLRs and sphingolipids.
Understanding and exploiting the interactions between these parasites and the host regulatory network are likely to highlight new strategies to control both infectious and immunological diseases.
American Psychological Association (APA)
Rajasekaran, Sivaprakasam& Anuradha, Rajamanickam& Bethunaickan, Ramalingam. 2017. TLR Specific Immune Responses against Helminth Infections. Journal of Parasitology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1186225
Modern Language Association (MLA)
Rajasekaran, Sivaprakasam…[et al.]. TLR Specific Immune Responses against Helminth Infections. Journal of Parasitology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1186225
American Medical Association (AMA)
Rajasekaran, Sivaprakasam& Anuradha, Rajamanickam& Bethunaickan, Ramalingam. TLR Specific Immune Responses against Helminth Infections. Journal of Parasitology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1186225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186225