CLU Polymorphisms in Patients with Pseudoexfoliation Syndrome in Polish Population
Joint Authors
Stafiej, Joanna
Malukiewicz, Grażyna
Linkowska, Katarzyna
Grzybowski, Tomasz
Swobodziński, Jacek
Lesiewska-Junk, Hanna
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Purpose.
To evaluate CLU polymorphisms in patients with pseudoexfoliation syndrome.
Materials and Methods.
We studied 81 patients (23 males and 58 females, the median age 76 years) and 91 control subjects (27 males and 64 females, the median age 75 years).
Genotypes of the CLU polymorphisms (SNPs), rs3087554 and rs2279590, were determined using a commercially available validated genotyping assays.
The χ2 test was performed to compare patient and control groups for possible associations between SNP genotype/allele frequency and disease state.
Results.
There were no significant differences for both allele and genotype frequencies between PEX patients and controls for rs3087554 and rs2279590 polymorphisms.
The haplotypes distribution shows statistically significant difference between groups p=0.03.
The haplotype (CT) more often was found in controls than in PEX patients, conferring an 18-fold decreased risk to the disease.
Conclusion.
Our results indicate that CLU variants may contribute to the risk of PEX in the Polish population.
American Psychological Association (APA)
Lesiewska-Junk, Hanna& Linkowska, Katarzyna& Stafiej, Joanna& Grzybowski, Tomasz& Swobodziński, Jacek& Malukiewicz, Grażyna. 2019. CLU Polymorphisms in Patients with Pseudoexfoliation Syndrome in Polish Population. Journal of Ophthalmology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1186327
Modern Language Association (MLA)
Lesiewska-Junk, Hanna…[et al.]. CLU Polymorphisms in Patients with Pseudoexfoliation Syndrome in Polish Population. Journal of Ophthalmology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1186327
American Medical Association (AMA)
Lesiewska-Junk, Hanna& Linkowska, Katarzyna& Stafiej, Joanna& Grzybowski, Tomasz& Swobodziński, Jacek& Malukiewicz, Grażyna. CLU Polymorphisms in Patients with Pseudoexfoliation Syndrome in Polish Population. Journal of Ophthalmology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1186327
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186327