Monitoring of Cellular Changes in the Bone Marrow following PTH(1-34) Treatment of OVX Rats Using a Portable Stray-Field NMR Scanner
Joint Authors
Hillel, Inbar
Binderman, Itzhak
Sarda, Yifat
Nevo, Uri
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Osteoporosis is characterized by reduction in trabecular bone in conjunction with increased marrow cell adiposity.
While these changes occur within weeks, monitoring of treatment efficacy as performed by DEXA is sensitive only to long-term changes.
MRI is sensitive to bone marrow changes but is less affordable.
In a recent study, we have shown that a stray-field NMR can monitor bone marrow cellular changes that are related to osteoporosis.
Objectives.
To demonstrate sensitivity of a low-field tabletop NMR scanner to bone marrow dynamics following hormonal treatment in rats.
Methods.
Two-month-old female rats (n=36) were ovariectomized (OVX) and dosed for the ensuing 3 or 5 weeks with 20 mg/kg of PTH(1-34).
Hind limbs femurs and tibiae were isolated and underwent ex vivo microradiography and histology and NMR relaxometry at 6 weeks (preventive experiment) and 11 weeks (therapeutic treatment experiment) after OVX.
Results.
OVX rats developed osteoporotic changes including adipogenic marrow compared to Sham and PTH treated rats.
T2 and ADC NMR relaxation coefficients were found to correlate with marrow composition.
Conclusions.
This study suggests that stray-field NMR, an affordable method that is sensitive to the rapid cellular changes in bone marrow, may have a clinical value in monitoring hormonal treatment for osteoporosis.
American Psychological Association (APA)
Hillel, Inbar& Binderman, Itzhak& Sarda, Yifat& Nevo, Uri. 2017. Monitoring of Cellular Changes in the Bone Marrow following PTH(1-34) Treatment of OVX Rats Using a Portable Stray-Field NMR Scanner. Journal of Osteoporosis،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1186369
Modern Language Association (MLA)
Hillel, Inbar…[et al.]. Monitoring of Cellular Changes in the Bone Marrow following PTH(1-34) Treatment of OVX Rats Using a Portable Stray-Field NMR Scanner. Journal of Osteoporosis No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1186369
American Medical Association (AMA)
Hillel, Inbar& Binderman, Itzhak& Sarda, Yifat& Nevo, Uri. Monitoring of Cellular Changes in the Bone Marrow following PTH(1-34) Treatment of OVX Rats Using a Portable Stray-Field NMR Scanner. Journal of Osteoporosis. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1186369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186369