The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis
Joint Authors
Zhou, Hongyan
Zhang, Hong
Xu, Chu-Yang
Zhang, Wen-Song
Cao, Yan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The studies outlined in this review highlight the relationship between inflammatory signaling molecules and connexin-43 (Cx43).
Gap junction (GJ) channels and hemichannels (HCs) participate in the metabolic activity between intra- and extracellular space.
Some ions and small molecules are exchanged from cell to cell or cell to extracellular space to affect the process of inflammation via GJ.
We analyzed the effects of signaling molecules, such as innate immunity messengers, transcription factors, LPS, cytokine, inflammatory chemokines, and MMPs, on Cx43 expression during the inflammatory process.
At the same time, we found that these signaling molecules play a critical role in the pathogenesis of keratitis.
Thus, we assessed the function of Cx43 during inflammatory corneal disease.
Corneal healing plays an essential role in the late stage of keratitis.
We found that Cx43 is involved in wound healing.
Studies have shown that the decrease of Cx43 can decrease the time of healing.
We also report several Cx43 mimic peptides which can inhibit the activity of Cx43 Hc to mediate the releasing of adenosine triphosphate (ATP), which may in turn influence the inflammatory process.
American Psychological Association (APA)
Xu, Chu-Yang& Zhang, Wen-Song& Zhang, Hong& Cao, Yan& Zhou, Hongyan. 2019. The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis. Journal of Ophthalmology،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1186431
Modern Language Association (MLA)
Xu, Chu-Yang…[et al.]. The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis. Journal of Ophthalmology No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1186431
American Medical Association (AMA)
Xu, Chu-Yang& Zhang, Wen-Song& Zhang, Hong& Cao, Yan& Zhou, Hongyan. The Role of Connexin-43 in the Inflammatory Process: A New Potential Therapy to Influence Keratitis. Journal of Ophthalmology. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1186431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1186431