Twenty-Four-Hour Contact Lens Sensor Monitoring of Aqueous Humor Dynamics in Surgically or Medically Treated Glaucoma Patients

Abstract EN

Aim.

This study assessed the 24 h circadian rhythm of intraocular pressure (IOP) using a contact lens sensor in three groups of patients with open-angle glaucoma.

Methods.

This study was a monocentric, cross-sectional, nonrandomized, prospective, pilot study.

Eighty-nine patients were enrolled: 29 patients previously underwent an Ex-PRESS mini glaucoma device procedure (Group 1), 28 patients previously underwent Hydrus microstent implantation (Group 2), and 32 patients were currently being treated medically for primary open-angle glaucoma (Group 3).

Circadian rhythm patterns were considered with five circadian indicators: fluctuation ranges, maximum, minimum, acrophase (time of peak value), and bathyphase (time of trough value).

A two-tailed Mann–Whitney U-test was used to evaluate differences between groups.

Results.

All subjects exhibited a circadian rhythm and a nocturnal pattern.

The signal fluctuation range was significantly smaller in the surgical groups than in the medically treated group (Group 1 vs.

Group 3, p=0.003; Group 2 vs.

Group 3, p=0.010).

Subjects who underwent the Ex-PRESS procedure (Group 1) exhibited significant differences compared with the drug therapy group (Group 3) with regard to the minimum value (p=0.015), acrophase (p=0.009), and bathyphase (p=0.002).

The other circadian indicators were not significantly different among groups.

Conclusions.

Patients who underwent IOP-lowering surgery had an intrinsic nyctohemeral rhythm.

Both surgical procedures, Ex-PRESS and Hydrus, were associated with smaller signal fluctuations compared with medical treatment.